- The GRADE approach results in an assessment of the quality of a body of evidence in one of four grades: high, moderate, low, or very low. For each outcome, the quality of evidence started at high, were downgraded by one level when there was a serious issue identified, and were downgraded by two levels when there was a very serious issue identified in each factor to judge the quality of evidence
- PCT procalcitonin, P-SEP presepsin, QoE quality of evidence
- 1)We downgraded all outcomes for risk of bias because all of the included studies presented an unclear or high risk of index test interpretation bias
- 2)We downgraded all outcomes for inconsistency because there were substantial heterogeneities among pooled results of sensitivity and specificity
- 3)We ranked the importance of all the four outcomes as critical