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Table 1 Characteristics of the included studies

From: Diagnostic value of procalcitonin and presepsin for sepsis in critically ill adult patients: a systematic review and meta-analysis

Author, year Country Number of participants Mean/median age Study design Sepsis definition Cutoff value Prevalence Sensitivity Specificity
PCT (ng/ml) P-SEP (pg/ml) PCT P-SEP PCT P-SEP
Ali, 2016 [21] Egypt 51 49.8 Prospective Sepsis-3 0.85 907 0.647 60.6% 69.7% 88.9% 83.3%
Balci, 2003 [22] Turkey 89 58 Prospective Sepsis-1 2.415 0.461 85.4% 91.7%
Bauer, 2016 [23] USA 219 59 Prospective Sepsis-1 0.74 0.551 73.1% 74.2%
Behnes, 2014 [24] Germany 116 62 Prospective Sepsis-2 530 0.705 91.0% 53.6%
ÇakirMadenci, 2014 [25] Turkey 37 40 Prospective ABA 2007a) 0.759 542 0.393 75.4% 77.5% 78.7% 76.5%
Endo 2012 [11] Japan 185 66 Prospective Sepsis-2 0.5 600 0.622 86.1% 87.8% 78.6% 81.4%
Enguix-Armada 2016 [26] Spain 388 63 Prospective Sepsis-2 0.28 101.6 0.634 92.3% 81.7% 96.5% 96.5%
Gibot 2004 [27] France 76 60 Prospective Sepsis-1 0.6 0.618 83.0% 69.0%
Godnic 2015 [28] Slovenia 47 N.A. Retrospective Sepsis-2 3.12 413 0.851 57.5% 85.0% 71.4% 57.1%
Klouche 2016 [29] France 144 58 Prospective Sepsis-1 0.5 466 0.694 80.0% 90.0% 59.1% 54.5%
Leli 2016 [30] Italy 92 73 Prospective Sepsis-1 4.4 843.5 0.281 84.0% 88.0% 84.4% 71.9%
Miglietta 2015 [31] Italy 145 64.4 Retrospective Sepsis-1 0.88 0.625 85.7% 83.3%
Romualdo 2014 Spain 226 67 Prospective Original 0.45 729 0.164 75.7% 81.1% 64.0% 63.0%
Selberg 2000 [32] Germany 33 47.9 Prospective Sepsis-1 3.3 0.667 86.4% 54.5%
Takahashi 2016 [33] Japan 103 68 Prospective Sepsis-1 0.85 658 0.85 78.8% 72.9% 73.3% 60.0%
Ugarte 1999 [34] Belgium 190 62 Prospective Sepsis-1 0.6 0.584 67.6% 60.8%
vanderGeest 2016 [35] Netherlands 301 57 Prospective Original 1.41 0.505 65.1% 66.4%
Wong 2013 [36] France 270 61 Prospective Not described 0.5 0.537 88.3% 64.0%
Yang 2016 [37] China 300 64 Prospective Sepsis-1 0.4475 0.357 83.2% 53.9%
  1. PCT procalcitonin, P-SEP presepsin
  2. a)American Burn Association Consensus Criteria