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Table 1 Characteristics of included studies

From: Terlipressin for septic shock patients: a meta-analysis of randomized controlled study

Study ID Setting Type of shock   Patient characteristics   
Number of participants Mean age (years) Prognostic index Baseline mean MAP (mmHg) Baseline mean LAC (mmol/L) Regimen Target MAP (mmHg)
Albanèse 2005 [13] Mix-ICU SS TP (n = 10) 66 28 (A II) 54 NR TP 1 mg bolus once or twice 65–75
NE (n = 10) 65 29 (A II) 54 NE 0.3 μg/kg/min followed by 0.3 μg/kg/min increments at 4-min intervals
Yildizdas 2008 [14] PICU CRSS TP (n = 30) 2 26.4 (P) 56 NR TP 20 μg/kg bolus every 6 h for at most 96 h > 2 SD for age
DA+DB (n = 28) 2 27.9 (P) 56 DA 0–20 μg/kg/min, DB 0-15 μg/kg/min, if need E 0–2 μg/kg/min
Morelli 2008 [9] Mix-ICU SS TP+NE (n = 19) 66 60 (S II) 74 3 TP 1 mg bolus, NE 0.9 μg/kg/min 65–75
TP+DB+NE (n = 20) 66 61 (S II) 72 3 TP 1 mg bolus, DB 3–20 μg/kg/min, NE 0.9 μg/kg/min
NE (n = 20) 67 59 (S II) 73 3 NE titrated
Morelli 2009 [10] Mix-ICU SS TP (n = 15) 67 62 (S II) 53 3 TP 1.3 μg/kg/h 65–75
NE (n = 15) 64 58 (S II) 54 3 NE 15 μg/min
Svoboda 2012 [2] TICU CRSS TP (n = 13) 70 18 (SOFA) 71 7 TP 4 mg/24 h 65–75
NE (n = 17) 75 18 (SOFA) 74 8 NE titrated
Hua 2013 [21] Mix-ICU ARDS+shock TP (n = 16) 57 19 (A II); 42 (S II) 59 NR TP 1.4 μg/kg/h 65–75
DA (n = 16) 52 18 (A II); 48 (S II) 58 DA 0–20 μg/kg/min
Xiao 2015 [22] Mix-ICU SS TP+NE (n = 15) 62 NR 66 3.2 TP 1.3 μg/kg/h 65–90
NE (n = 17) 63 64 3.6 NE titrated
Choudhury 2016 [24] LICU Cirrhosis+SS TP (n = 42) 47 14 (SOFA) 61 3 TP 1.3–5.2 μg/min ≥ 65
NE (n = 42) 48 15 (SOFA) 60 3 NE 7.5-60 μg/min
Chen 2017 [23] Mix-ICU ARDS+SS TP (n = 31) 59 23 (A II) 55 NR TP 0.01–0.04 U/min 65–75
NE (n = 26) 56 21 (A II) 54 NE titrated
Liu 2018 [8] Mix-ICU SS TP (N = 260) 61 19 (A II); 11 (SOFA) 68 4 TP 20-160 μg/h 65–75
NE (n = 266) 61 19 (A II); 11 (SOFA) 68 4 NE 4-160 μg/h
  1. A II acute physiology and chronic health evaluation II, ARDS acute respiratory distress syndrome, CRSS catecholamine-resistant septic shock, DA dopamine, DB dobutamine, E epinephrine, LAC lactate, LICU liver intensive care unit, MAP mean arterial pressure, Mix-ICU intensive care unit, NE noradrenaline, NR not report, P pediatric risk of mortality, PICU pediatric intensive care unit, S II simplified acute physiologic score II, SD standard deviation, SOFA sequential organ failure assessment score, SS septic shock, TICU trauma intensive care unit, TP terlipressin