Table 2 Demographic and clinical characteristics of the study cohort (N=249). Comparator = unanimous method, meaning that the site investigators’ consensus discharge assessment and the individual evaluations by the three external RPD panelists were in complete agreement, regarding the diagnosis of SIRS or sepsis. If the agreement was less than unanimous, then an indeterminate call was made

Demographics

Age: median (IQR)

54 (40–65)

60 (47–67)

64 (53–75)

0.002

Sex: female

51 (48%)

30 (44%)

36 (49%)

0.79

White

68 (64%)

41 (59%)

53 (72%)

0.30

Black

30 (28%)

16 (23%)

16 (22%)

0.55

Asian/East Indian

2 (2%)

6 (9%)

2 (3%)

0.06

Hispanic

4 (4%)

5 (7%)

3 (4%)

0.54

Other or unrecorded

2 (2%)

1 (1%)

0

0.51

Blood culture result

1. No blood culture done or blood culture negative

100 (94%)

11 (16%)

66 (89%)

< 0.001

2. Blood culture positive

3 (3%)

29 (42%)

4 (5%)

< 0.001

3. Gram positive

3 (3%)

13 (19%)

3 (4%)

< 0.001

4. Gram negative

0

11 (16%)

1 (1%)

< 0.001

5. Mixed Gram pos/neg

0

5 (7%)

0

0.001

6. Fungus

0

0

0

NA

Infection site

Respiratory tract (non-lung)

0

3 (4%)

4 (5%)

0.06

Lung (pneumonia)

3 (3%)

15 (22%)

24 (32%)

< 0.001

Abdominal

0

10 (14%)

2 (3%)

< 0.001

Urinary tract

0

8 (12%)

3 (4%)

0.001

Other site

0

21 (30%)

4 (5%)

< 0.001

Not identified

103 (97%)

12 (17%)

37 (50%)

< 0.001

Clinical parameters, outcome

Days in hospital: median (IQR)

3 (2–5)

8 (5–14)³

6 (4–9)

< 0.001

Days in ICU: median (IQR)

2 (1–2)

3 (2–5)

2 (1–4)

0.002

Antibiotics given in ICU

60 (57%)

68 (99%)

68 (92%)

< 0.001

APACHE score: median (IQR)²

54 (29–84)

76 (46–95)³

82 (48–103)⁴

< 0.001

SOFA score: median (IQR)

4 (2–7)⁶

5 (4–10)⁵

6 (4–8)⁷

0.02

Mortality

6 (6%)

9 (13%)³

9 (12%)

0.18