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Table 1 Clinical diagnostic methods

From: Physician agreement on the diagnosis of sepsis in the intensive care unit: estimation of concordance and analysis of underlying factors in a multicenter cohort

  Classification method
1. Initial assessment: attending physician 2. Initial assessment: site investigator 3. Discharge assessment: site investigators 4. External RPD
By: Attending physician (N = 1) Site investigator (N = 1) Site investigators (N = 2) External expert panel (N = 3)
When: Within 24 h of admission to ICU Within 48 h of admission to ICU (nearly always within 24 h) At discharge from ICU Following discharge from ICU
Using: Clinical signs at admission and basic laboratory and radiology results Clinical signs at admission and basic laboratory and radiology results • Retrospective data (first 24 h in ICU)
• Microbiology
• Non-culture based pathogen detection results
• Radiology
• Retrospective data (first 24 h in ICU)
• Microbiology
• Non-culture-based pathogen detection results
• Radiology
• Retrospective discharge assessment
Output SIRS/indeterminate/sepsis SIRS/indeterminate/sepsis SIRS/indeterminate/sepsis SIRS/indeterminate/sepsis
Adjudication None None If site investigators do not agree, then 3rd independent physician’s vote taken Full agreement = SIRS or sepsis
2/3 agreement = SIRS or sepsis
No agreement = Indeterminate