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Table 3 Multivariable logistic regression for 28-day mortality, with covariates of diastolic grade (adjusted for admission APACHE II score, mechanical ventilation at time of echocardiogram, and vasopressor dose at time of echocardiogram) for all three definitions. For patients on multiple vasopressors, all doses were converted to norepinephrine-equivalent doses, as per the previously described methods [27]

From: A simplified definition of diastolic function in sepsis, compared against standard definitions

Covariate Odds ratio 95% confidence interval p value
ASE 2009
 Diastolic grade (0–3) 1.00 (0.56, 1.64) 0.99
 APACHE II 1.14 (1.08, 1.23) < 0.001
 Mechanical ventilation 0.60 (0.19, 1.70) 0.35
 Vasopressor dose (per 1 mg/kg/min increase norepinephrine equivalent) 1.02 (1.00, 1.04) 0.08
ASE 2016
 Diastolic grade (0–3) 1.37 (0.97, 1.94) 0.07
 APACHE II 1.13 (1.09, 1.18) < 0.001
 Mechanical ventilation 0.43 (0.18, 0.98) 0.05
 Vasopressor dose (per 1 mg/kg/min increase norepinephrine equivalent) 1.01 (1.00, 1.03) 0.12
Simplified
 Diastolic grade (0–3) 1.16 (0.91, 1.49) 0.24
 APACHE II 1.12 (1.08, 1.17) < 0.001
 Mechanical ventilation 0.37 (0.16, 0.81) 0.02
 Vasopressor dose (per 1 mg/kg/min increase norepinephrine equivalent) 1.02 (1.01, 1.04) 0.02