Table 3 Comparison of clinical outcome and laboratory data between the pre-ECMO team and post-ECMO team established
All patients (n = 69) | Pre-ECMO team (n = 27) | Post-ECMO team (n = 42) | p value | |
|---|---|---|---|---|
Time from cannulation to ECMO started (min), median (IQR) | 15 (6.5–32.5) | 16 (15–52) | 15 (6–32) | 0.37 |
Duration of ECMO (days) | 3 (1–4) | 3 (1–4) | 3 (2–5) | 0.65 |
Length of mechanical ventilation (days) | 10 (6–16) | 11 (7–23) | 8 (5–14) | 0.21 |
Length of ICU stay (days) | 16 (9–23) | 18 (9–30) | 16 (8–20) | 0.17 |
Length of hospital stay (days) | 51 (25–76) | 55 (27–125) | 51 (22–70) | 0.30 |
Before ECMO, median (IQR) | ||||
PH | 7.22 (7.05–7.38) | 7.19 (7.03–7.44) | 7.23 (7.07–7.36) | 0.86 |
PaCO2 (mmHg) | 38 (48–68) | 47 (40–87) | 49 (37–66) | 0.39 |
PaO2 (mmHg) | 103 (55–169) | 85 (41–121) | 122 (75–246) | 0.13 |
HCO3 (cmH2O) | 21 (15–26) | 22 (15–28) | 20 (15–25) | 0.28 |
Lactate (mmol/L) | 9.9 (4.1–14.15) | 7.7 (3.4–15.5) | 10.5 (5.3–13.8) | 0.88 |
FiO2 | 0.6 (0.5–1.0) | 0.8 (0.6–1.0) | 0.6 (0.50–1.00) | 0.57 |
PEEP (cmH2O) | 8 (5–10) | 9 (6–10) | 8 (4–10) | 0.74 |
On-ECMO 6 h, median (IQR) | ||||
PH | 7.42 (7.34–7.50) | 7.44 (7.35–7.51) | 7.41 (7.33–7.49) | 0.47 |
PaCO2 (mmHg) | 32 (27–39) | 31 (25–36) | 33 (27–40) | 0.36 |
PaO2 (mmHg) | 322 (148–470) | 239 (113–430) | 367 (186–490) | 0.047 |
HCO3 (cmH2O) | 21 (18–24) | 20 (16–26) | 22 (18–24) | 0.71 |
Lactate (mmol/L) | 5.8 (4.4–9.1) | 5.9 (4.7–8.7) | 5.8 (3.4–9.8) | 0.74 |
FiO2 | 0.5 (0.4–0.6) | 0.6 (0.5–0.7) | 0.5 (0.4–0.6) | 0.38 |
PEEP (cmH2O) | 8 (5–10) | 7 (5–8) | 8 (5–10) | 0.01 |
ACT (seconds) | 187 (165–207) | 201 (168–214) | 185 (160–202) | 0.23 |
ECMO blood flow (L/min) | 2.2 (1.9–2.8) | 2.2 (2.0–3.0) | 2.2 (1.8–2.6) | 0.36 |
On-ECMO 24 h, median IQR | ||||
PaO2/FiO2 | 462 (264–672) | 438 (208–598) | 469 (299–740) | 0.18 |
PH | 7.43 (7.38–7.52) | 7.44 (7.38–7.55) | 7.42 (7.37–7.51) | 0.26 |
PaCO2 (mmHg) | 36 (29–40) | 33 (27–39) | 36 (30–42) | 0.30 |
PaO2 (mmHg) | 221 (133–322) | 210 (125–274) | 246 (136–350) | 0.28 |
HCO3 (cmH2O) | 24 (22–27) | 25 (19–29) | 24 (22–27) | 0.62 |
Lactate (mmol/L) | 2.8 (1.9–4.4) | 3.2 (2.8–4.9) | 2.6 (1.3–4.4) | 0.19 |
FiO2 | 0.4 (0.4–0.6) | 0.5 (0.4–0.6) | 0.4 (0.4–0.5) | 0.08 |
PEEP (cmH2O) | 8 (6–10) | 8 (5–10) | 8 (7–10) | 0.57 |
ACT (seconds) | 182 (161–196) | 182 (160–196) | 186 (163–197) | 0.54 |
ECMO blood flow (L/min) | 2.2 (1.7–3.0) | 2.3 (1.9–3.0) | 2.2 (1.7–3.1) | 0.63 |
Lactate clearance, median (IQR) | ||||
At 6 h (%) | 15 (−27 to 54) | 4 (−51 to 57) | 18 (−17 to 54) | 0.59 |
At 24 h (%) | 61 (18 to 80) | 51 (−20 to 83) | 61 (18 to 80) | 0.71 |