Fig. 1

Time course of laboratory parameters and treatments. Panels a and b show changes in bio-chemical parameters and coagulation factors. Note that after the supplementation of ATIII concentrate, AST and ALT (a) remarkably decreased with associations of PT and PLT (b) improvements. CRP (a) did not respond despite high IL-6 levels (a), after ATIII concentrate, unexpectedly increased, which might show a possible improvement in hepatic CRP synthesis. Panels c and d demonstrate prominent elevations in TAT (c), FDP and PIC (d) in the early phase, which was accompanied with a steep drop in α₂PI (d). tPAI-1 (d) increased gradually, peaking on day 3, which was followed by a sustained SF (c) soaring. Although TAT dropped gradually, SF augmentation was not attenuated. After the combined administration of rh-TM-α and ATIII concentrate, further decrease in TAT with a gradual fall in SF occurred, along with changes in bio-chemical parameters stated above