Table 3 Decline in thigh muscle thickness and outcome
Muscle thickness | Day1 | Day3 | Day5 | Day7 |
|---|---|---|---|---|
a. In-hospital mortality | ||||
Survivors (n) | 59 | 59 | 53 | 28 |
Muscle thickness (mean ± SD) | 31.3 ± 8.5 | 30.2 ± 8.3 | 29.6 ± 8.0 | 30.4 ± 7.4 |
% Decline [median (IQR)] | NA | 2.6(1.4,5.1) | 3.7(2.8, 8.3) | 4.8(3.6, 9.8) |
Non-Survivors (n) | 11 | 11 | 10 | 7 |
Muscle thickness (mean ± SD) | 30.9 ± 9.4 | 28.5 ± 9.0 | 27.6 ± 8.7 | 26.4 ± 8.7 |
% Decline [median (IQR)] | NA | 7.5(5.2, 11.4) | 13.0(10.0, 15.7) | 15.5(10.4, 17.8) |
p value (% decline) | NA | < 0.001 | < 0.001 | < 0.003 |
b. ICU-acquired weakness | ||||
Absent (n) | 55 | 55 | 48 | 23 |
Muscle thickness (mean ± SD) | 31.5 ± 8.1 | 30.3 ± 7.8 | 29.9 ± 7.2 | 29.9 ± 6.8 |
% Decline [median (IQR)] | NA | 2.9 (1.6, 5.2) | 3.7 (2.9, 9.1) | 5.1 (3.3, 10.4) |
Present (n) | 15 | 15 | 15 | 12 |
Muscle thickness (mean ± SD) | 30.2 ± 10.3 | 28.5 ± 10.4 | 27.3 ± 10.4 | 28.9 ± 9.5 |
% Decline [median (IQR)] | NA | 5.7 (2.9, 8.4) | 9.9 (5.5, 13.0) | 11.0 (6.5, 16.8) |
p value (% decline) | NA | 0.04 | 0.02 | 0.02 |
c. 90-days outcome | ||||
Stable outcome (n) | 42 | 42 | 36 | 17 |
Muscle thickness (mean ± SD) | 31.7 ± 7.9 | 31.0 ± 7.7 | 30.9 ± 7.0 | 31.6 ± 6.6 |
% Decline [median (IQR)] | NA | 2.1 (− 5.0, 7.9) | 3.1 (− 2.0, 9.6) | 4.2 (− 2.6, 9.1) |
Poor outcome (n) | 17 | 17 | 17 | 11 |
Muscle thickness (mean ± SD) | 30.1 ± 9.9 | 28.2 ± 9.6 | 26.8 ± 9.3 | 28.5 ± 8.6 |
% Decline [median (IQR)] | NA | 5.7 (0.8, 14.4) | 9.9 (3.5, 26.9) | 10.9 (2.7, 33.7) |
p value (% decline) | NA | < 0.0001 | < 0.0001 | 0.0003 |