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Fig. 2 | Journal of Intensive Care

Fig. 2

From: Circulating histone H3 levels are increased in septic mice in a neutrophil-dependent manner: preclinical evaluation of a novel sandwich ELISA for histone H3

Fig. 2

Circulating histone H3 levels are elevated in mice with CLP. Serum histone H3 levels in C57BL/6 J mice with CLP-induced sepsis or sham operation are shown. Serum samples were collected at 6, 12, 24, and 36 h after CLP (n = 6–12 per group) or sham operation (n = 4–10 per group). Representative data of two or more independent experiments are shown. Differences in circulating histone H3 levels between CLP mice and sham mice were analyzed by the Mann–Whitney U test. *p < 0.05, **p < 0.01

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