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Table 2 C. auris virulence and resistance factors

From: Epidemiology, clinical characteristics, resistance, and treatment of infections by Candida auris

Virulence genes encoding for:
 Hemolysin, secreted aspartyl proteinases, secreted lipases, phosphatases, mannosyl transferases, phospholipase, integrins, adhesins, Zn(II) 2 cys 6 transcription factor (strain-specif degree of activity)
Resistance genes:
Azoles resistance
 Transport proteins and efflux pumps (ATP-binding cassette ABC; major facilitator superfamilies MFS; upregulation of CDR1, CDR2, MDR1)
ERG 11 mutations (substitutions Y132F, K143R, and F126T) and ERG 11 upregulation
Echinocandin resistance
FKS1/2 (encoding echinocandin drug target 1,3-beta-glucan synthase)
Adherence to surfaces and plastic materials (e.g., catheters)
Biofilm formation
Cellular morphology (aggregating and non-aggregating forms)
Rudimentary pseudohyphae formation