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Table 2 Mean biomarker concentrations and APACHE II scores at enrollment (T0) stratified by sepsis categories (maximum sepsis severity achieved)

From: Evaluating the discriminating capacity of cell death (apoptotic) biomarkers in sepsis

  cfDNA (μg/ml)
Mean (SD)6
Nucleosome (μg/ml)
Mean (SD)7
APACHE II
Mean (SD)9
5,8PCT (ng/ml)
Mean (SD)
Non-infectious SIRS1 (N = 24) 3.0 (1.5) 1.1 (1.7) 8.3 (4.7) 7.5 (24.8)
Uncomplicated sepsis2 (N = 4) 3.6 (1.0) 1.7 (1.9) 11.5 (3.8) 0.4 (0.4)
Severe sepsis3 (N = 127) 3.9 (4.3) 3.0 (9.4) 9.0 (5.3) 6.5 (15.6)
Shock4 (N = 35) 4.8 (5.8) 5.5 (10.9) 15.5 (6.3) 20.7 (34.4)
Survivors (N = 190) 3.9 (4.3) 3.2 (9.1) 10.1 (5.9) 9.1 (21.9)
Non-survivors (N = 13) 3.9 (1.4) 5.0 (4.9) 17.5 (5.9)
  1. 1SIRS (no infection with two or more of the following): 1 temp > 38.3 or < 36 °C, 2 heart rate > 90 bpm, 3 tachypnea resp. > 20 bpm or pCO2 < 32 mmHg, 4 WBC < 4000mm3 or > 12,000mm3 or 10% bands
  2. 2Sepsis (infection with two or more of the aforementioned SIRS criteria)
  3. 3Severe sepsis: sepsis accompanied by organ dysfunction: 1 arterial hypotension (SAP < 90 mmHg, MAP < 70 mmHg), 2 reduced urine output (< 0.5 mL/kg/h for > 2 h); 3 acute lung injury (PaO2/FIO2 < 250 if without pneumonia or < 200 if afflicted with pneumonia) based on the ACCP/SCCM consensus document. The following organ systems surveillance was available: cardiovascular, pulmonary, renal, and hematologic
  4. 4Septic shock: sepsis-induced hypotension persisting despite adequate fluid resuscitation
  5. 5There were only three subjects available in the non-survivor group in which the PCT level was available
  6. 6Significance between SIRS and sepsis (p = 0.009), SIRS and severe sepsis (p = 0.02), SIRS and septic shock (p = 0.01), and SIRS and death (p = 0.04)
  7. No significance between survivors and non-survivors
  8. 7Significance between SIRS and septic shock (p = 0.012); between SIRS and death (p = 0.001); between severe sepsis and death (p = 0.003); between sepsis vice SIRS (p = 0.036); between survivors and non-survivors (p = 0.007)
  9. 8Significance between SIRS and septic shock (p = 0.002); SIRS and severe sepsis (p < 0.002)
  10. 9Significance between SIRS and septic shock (p < 0.001); between SIRS and death (p < 0.001); between severe sepsis and septic shock and death (p < 0.001); between SIRS and sepsis (p = 0.044); between survivors and non-survivors (p < 0.001)