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Table 2 Mean biomarker concentrations and APACHE II scores at enrollment (T0) stratified by sepsis categories (maximum sepsis severity achieved)

From: Evaluating the discriminating capacity of cell death (apoptotic) biomarkers in sepsis

 

cfDNA (μg/ml)

Mean (SD)6

Nucleosome (μg/ml)

Mean (SD)7

APACHE II

Mean (SD)9

5,8PCT (ng/ml)

Mean (SD)

Non-infectious SIRS1 (N = 24)

3.0 (1.5)

1.1 (1.7)

8.3 (4.7)

7.5 (24.8)

Uncomplicated sepsis2 (N = 4)

3.6 (1.0)

1.7 (1.9)

11.5 (3.8)

0.4 (0.4)

Severe sepsis3 (N = 127)

3.9 (4.3)

3.0 (9.4)

9.0 (5.3)

6.5 (15.6)

Shock4 (N = 35)

4.8 (5.8)

5.5 (10.9)

15.5 (6.3)

20.7 (34.4)

Survivors (N = 190)

3.9 (4.3)

3.2 (9.1)

10.1 (5.9)

9.1 (21.9)

Non-survivors (N = 13)

3.9 (1.4)

5.0 (4.9)

17.5 (5.9)

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  1. 1SIRS (no infection with two or more of the following): 1 temp > 38.3 or < 36 °C, 2 heart rate > 90 bpm, 3 tachypnea resp. > 20 bpm or pCO2 < 32 mmHg, 4 WBC < 4000mm3 or > 12,000mm3 or 10% bands
  2. 2Sepsis (infection with two or more of the aforementioned SIRS criteria)
  3. 3Severe sepsis: sepsis accompanied by organ dysfunction: 1 arterial hypotension (SAP < 90 mmHg, MAP < 70 mmHg), 2 reduced urine output (< 0.5 mL/kg/h for > 2 h); 3 acute lung injury (PaO2/FIO2 < 250 if without pneumonia or < 200 if afflicted with pneumonia) based on the ACCP/SCCM consensus document. The following organ systems surveillance was available: cardiovascular, pulmonary, renal, and hematologic
  4. 4Septic shock: sepsis-induced hypotension persisting despite adequate fluid resuscitation
  5. 5There were only three subjects available in the non-survivor group in which the PCT level was available
  6. 6Significance between SIRS and sepsis (p = 0.009), SIRS and severe sepsis (p = 0.02), SIRS and septic shock (p = 0.01), and SIRS and death (p = 0.04)
  7. No significance between survivors and non-survivors
  8. 7Significance between SIRS and septic shock (p = 0.012); between SIRS and death (p = 0.001); between severe sepsis and death (p = 0.003); between sepsis vice SIRS (p = 0.036); between survivors and non-survivors (p = 0.007)
  9. 8Significance between SIRS and septic shock (p = 0.002); SIRS and severe sepsis (p < 0.002)
  10. 9Significance between SIRS and septic shock (p < 0.001); between SIRS and death (p < 0.001); between severe sepsis and septic shock and death (p < 0.001); between SIRS and sepsis (p = 0.044); between survivors and non-survivors (p < 0.001)
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Journal of Intensive Care

ISSN: 2052-0492