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Fig. 4 | Journal of Intensive Care

Fig. 4

From: Role of extracellular vesicles in the development of sepsis-induced coagulopathy

Fig. 4

Procoagulant activities of the extracellular vesicles. Monocytes and neutrophils play major roles in the activation in coagulation during sepsis. They express tissue factor on the cellular surface that initiates extrinsic pathway and also express phosphatidylserine that triggers intrinsic pathway of the coagulation cascades on the outer-envelope of the plasma membrane. Tissue factor and phosphatidylserine are also expressed on the surface of microvesicles released from the other parent cells such as platelets and endothelial cells

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