Fig. 1

Different types of extracellular vesicles. Leukocytes can produce extracellular vesicles in response to certain stimuli. Apoptotic bodies are the final form of apoptotic cell-death and are known to be engulfed by phagocytes. Exosomes are secreted after multivesicular bodies (MVBs) fuse with the plasma membrane. Exosomes contain messenger RNA and micro RNA and are released by exocytosis. Microvesicles that express tissue factor and adhesion molecules and that carry damage-associated molecular patterns are shed from leukocytes. Extracellular vesicles present procoagulant properties expressed by phosphatidylserine on their surfaces. PS phosphatidylserine, DAMPs damage-associated molecular patterns