Table 2 Demographic and clinical characteristics of pneumonia-associated septic shock patients by mortality
|
Died (n = 2141) |
Survived (n = 2081) | P value | |||
|---|---|---|---|---|---|
| N | Number (%) or mean (SD) | N | Number (%) or mean (SD) | ||
| Demographics | |||||
| Age | 2141 | 64.6 (15.8) | 2081 | 58.8 (16.7) | < 0.001 |
| Sex (male) | 2141 | 1323 (61.8) | 2081 | 1251 (60.1) | 0.277 |
| Body mass index | 974 | 26.6 (7.8) | 1039 | 27.7 (7.7) | 0.001 |
| Microbiology characteristics | |||||
| Concomitant bloodstream infection | 2141 | 484 (22.6) | 2081 | 392 (18.8) | 0.003 |
| Empyema | 2141 | 45 (2.1) | 2081 | 74 (3.6) | 0.010 |
| Culture positive | 2141 | 1421 (66.4) | 2081 | 1231 (59.2) | < 0.001 |
| Gram positive | 2141 | 696 (32.5) | 2081 | 717 (34.5) | 0.191 |
| Gram negative | 2141 | 608 (28.4) | 2081 | 465 (22.3) | < 0.001 |
| Fungal | 2141 | 16 (0.7) | 2081 | 4 (0.2) | 0.009 |
| Hospital-acquired infection | 2141 | 957 (44.7) | 2081 | 590 (28.4) | < 0.001 |
| Organ failure/support | |||||
| APACHE | 2034 | 28.5 (8.0) | 1961 | 22.8 (6.7) | < 0.001 |
| Organ failure day 1 | 2141 | 4.2 (1.6) | 2081 | 3.4 (1.3) | < 0.001 |
| Mechanical ventilation | 2141 | 2005 (93.6) | 2081 | 1755 (84.3) | < 0.001 |
| Biochemistry (admission) | |||||
| WBC | 2052 | 16.3 (17.9) | 1979 | 16.4 (13.0) | 0.757 |
| Platelets | 2021 | 195 (143) | 2025 | 216 (128) | < 0.001 |
| Sodium | 1121 | 137.4 (7.2) | 1367 | 137.0 (7.0) | 0.192 |
| Creatinine | 1937 | 192.2 (164.6) | 1892 | 187.5 (164.6) | 0.377 |
| Lactate | 1447 | 5.1 (4.6) | 1357 | 3.1 (2.8) | < 0.001 |
| INR | 1848 | 1.9 (1.5) | 1847 | 1.6 (1.1) | < 0.001 |
| Bilirubin | 1768 | 39.7 (82.7) | 1776 | 20.1 (36.7) | < 0.001 |
| Albumin | 621 | 21.6 (6.3) | 885 | 23.5 (6.4) | < 0.001 |
| Immunocompromised | 2141 | 360 (16.8) | 2081 | 201 (9.7) | < 0.001 |
| Time delay from shock to appropriate antimicrobials (hours) | 1494 | 17.2 (23.6) | 1554 | 5.0 (5.6) | < 0.001 |