Table 1 Demographic and clinical characteristics of pneumonia-associated septic shock patients
Overall cohort (n = 4222) | ||
|---|---|---|
N | Number (%) or mean (SD) | |
Demographics | ||
Age | 4222 | 62 (17) |
Sex (male) | 4222 | 2574 (61.0) |
Body mass index | 2013 | 27 (8) |
Microbiology characteristics | ||
Concomitant bloodstream infection | 4222 | 876 (20.7) |
Empyema | 4222 | 119 (2.8) |
Culture positive | 4222 | 2652 (62.8) |
Gram positive | 4222 | 1413 (33.5) |
Gram negative | 4222 | 1073 (25.4) |
Fungal | 4222 | 20 (0.8) |
Hospital-acquired infection | 4222 | 1547 (36.6) |
Community-acquired infection | 4222 | 2675 (63.4) |
Organ failure/support | ||
APACHE | 3995 | 26 (8) |
Organ failure day 1 | 4222 | 3.8 (1.5) |
Mechanical ventilation | 4222 | 3760 (89.1) |
Biochemistry (admission) | ||
WBC | 4031 | 16.3 (15.7) |
Platelets | 4046 | 206 (136) |
Sodium | 2488 | 137.2 (7.1) |
Creatinine | 3829 | 189.9 (164.6) |
Lactate | 2804 | 4.1 (3.9) |
INR | 3695 | 1.7 (1.3) |
Bilirubin | 3544 | 29.9 (64.6) |
Albumin | 1506 | 22.7 (6.5) |
Immunocompromised | 4222 | 561 (13.3) |
Time delay from shock to appropriate antimicrobials (hours) | 3048 | 10.9 (18.6) |
Primary outcome: in-hospital mortality | 4222 | 2141 (50.7) |