From: The future of driving pressure: a primary goal for mechanical ventilation?
Trial name (trial number) | Trial design | Primary Investigator (country) | Intervention arm | Control arm | Primary outcome | Phase (June 2018) |
---|---|---|---|---|---|---|
DRiving pressure for Optimization of Positive end-expiratory pressure (DROP) [ACTRN12618000554268] | An uncontrolled clinical trial | Stephan Francois (France) | Decremental PEEP as part of standard care, where maximum PEEP for a plateau pressure < 30 cmH2O, then PEEP is set to 15, 10, and 5 cmH2O | Not applicable | Best PEEP level based on the best driving pressure value | Recruiting |
Does Automated Closed-Loop Ventilation Reduce the Driving Pressure Levels in Patients With ARDS (AiRDRoP) [NCT03211494] | A randomized crossover clinical trial | Marcus J Schultz (Netherlands) | Automated closed-loop ventilation | Conventional lung protective ventilation | Transpulmonary driving pressure up to day 7 | Recruiting |
Driving Pressure Limited Ventilation for Patients With ARDS (ART2pilot) [NCT02365038] | A multicenter randomized controlled pilot trial | Alexandre B Cavalcanti (Brazil) | A driving pressure limited mechanical ventilation strategy (driving pressure 13 cmH2O with adjusted tidal volume between 3 and 8 mL/kg of predicted body weight) | The ARDS Clinical Network strategy (tidal volume between 4 and 6 mL/kg of predicted body weight with limited plateau pressure up to 30 cmH2O) | Driving pressure between days 1 and 3 | Recruiting |