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Table 1 Clinical data and baseline characteristics of the study population

From: Monitoring of sedation depth in intensive care unit by therapeutic drug monitoring? A prospective observation study of medical intensive care patients

Baseline data

 Total number of patients

n = 49

 

 Average age (years) ± SD (range)

57.8 ± 16.0

(20–83)

 Gender

19 women/30 men

 

 Weight (kg) ± SD (range)

87.9 ± 27.7

(60–210)

 APACHE II Score ± SD (range)

13.1 ± 6.7

(2–27)

 SOFA Score ± SD (range)

17.8 ± 3.5

(9–23)

 Endotracheal ventilation

n = 49

 

 Analgosedation with sufentanil and midazolam

n = 49

 

 Total number of blood samples

n = 538

 

 Number of blood samples per patient (range)

11.0

(3–20)

Underlying disease

n

%

 Hematooncology

31

63.3

 COPD

7

14.3

 Nephrology

3

6.1

 Infectiology

2

4.1

 Cardiology

2

4.1

 None

4

8.2

Reason for ICU treatment

n

%

 Pneumonia

11

22.4

 Sepsis

11

22.4

 Sepsis + pneumonia

12

24.5

 Sepsis + acute renal failure

2

4.1

 ARDS

2

4.1

 GvHD

1

2.0

 Acute renal failure

3

6.1

 Cardial decompensation

2

4.1

 Hb-relevant bleeding

1

2.0

 Pneumonia + acute pancreatitis

1

2.0

 Mesenterial ischemia

1

2.0

 Coecum perforation

1

2.0

 Pneumonia + upper intestinal bleeding

1

2.0