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Table 1 Clinical data and baseline characteristics of the study population

From: Monitoring of sedation depth in intensive care unit by therapeutic drug monitoring? A prospective observation study of medical intensive care patients

Baseline data
 Total number of patients n = 49  
 Average age (years) ± SD (range) 57.8 ± 16.0 (20–83)
 Gender 19 women/30 men  
 Weight (kg) ± SD (range) 87.9 ± 27.7 (60–210)
 APACHE II Score ± SD (range) 13.1 ± 6.7 (2–27)
 SOFA Score ± SD (range) 17.8 ± 3.5 (9–23)
 Endotracheal ventilation n = 49  
 Analgosedation with sufentanil and midazolam n = 49  
 Total number of blood samples n = 538  
 Number of blood samples per patient (range) 11.0 (3–20)
Underlying disease n %
 Hematooncology 31 63.3
 COPD 7 14.3
 Nephrology 3 6.1
 Infectiology 2 4.1
 Cardiology 2 4.1
 None 4 8.2
Reason for ICU treatment n %
 Pneumonia 11 22.4
 Sepsis 11 22.4
 Sepsis + pneumonia 12 24.5
 Sepsis + acute renal failure 2 4.1
 ARDS 2 4.1
 GvHD 1 2.0
 Acute renal failure 3 6.1
 Cardial decompensation 2 4.1
 Hb-relevant bleeding 1 2.0
 Pneumonia + acute pancreatitis 1 2.0
 Mesenterial ischemia 1 2.0
 Coecum perforation 1 2.0
 Pneumonia + upper intestinal bleeding 1 2.0