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Table 5 Recommendations of cefepime dosing regimens for treating P. aeruginosa infections with various MICs in critically ill patients receiving CRRT

From: Cefepime dosing regimens in critically ill patients receiving continuous renal replacement therapy: a Monte Carlo simulation study

Actual MIC
(mg/L)
Target
MIC*
(mg/L)
Effluent rates (mL/kg/h) CVVH
(pre-hemofilter dilution)
CVVHD
1 4 10–15 250 mg Q8H 250 mg Q8H
20–25 250 mg Q8H 250 mg Q8H
35 250 mg Q8H 250 mg Q8H
2 8 10–15 750 mg LD then 500 mg Q12H 1 g LD then 500 mg Q12H
20–25 1 g LD then 500 mg Q12H 750 mg Q12H
35 750 mg Q12H 1 g Q12H
4 16 10–15 750 mg Q8H 1 g LD then 750 mg Q8H
20–25 1 g LD then 750 mg Q8H 1 g Q8H
35 1 g Q8H 1 g Q8H
8 32 10–15 1.75 g LD then 1.5 g Q8H 1.75 g LD then 1.5 g Q8H
20–25 2 g LD then 1.5 g Q8H 1.75 g Q8H
35 2 g LD then 1.75 g Q8H 2 g Q8H
  1. CVVH continuous venovenous hemofiltration, CVVHD continuous venovenous hemodialysis, LD loading dose
  2. *Pharmacodynamic target defined as at least 70% of the cumulative percentage of a 48-h period with four times MIC (70% fT>4MIC)