Table 5 Recommendations of cefepime dosing regimens for treating P. aeruginosa infections with various MICs in critically ill patients receiving CRRT
Actual MIC (mg/L) | Target MIC* (mg/L) | Effluent rates (mL/kg/h) | CVVH (pre-hemofilter dilution) | CVVHD |
|---|---|---|---|---|
1 | 4 | 10–15 | 250 mg Q8H | 250 mg Q8H |
20–25 | 250 mg Q8H | 250 mg Q8H | ||
35 | 250 mg Q8H | 250 mg Q8H | ||
2 | 8 | 10–15 | 750 mg LD then 500 mg Q12H | 1 g LD then 500 mg Q12H |
20–25 | 1 g LD then 500 mg Q12H | 750 mg Q12H | ||
35 | 750 mg Q12H | 1 g Q12H | ||
4 | 16 | 10–15 | 750 mg Q8H | 1 g LD then 750 mg Q8H |
20–25 | 1 g LD then 750 mg Q8H | 1 g Q8H | ||
35 | 1 g Q8H | 1 g Q8H | ||
8 | 32 | 10–15 | 1.75 g LD then 1.5 g Q8H | 1.75 g LD then 1.5 g Q8H |
20–25 | 2 g LD then 1.5 g Q8H | 1.75 g Q8H | ||
35 | 2 g LD then 1.75 g Q8H | 2 g Q8H |