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Table 4 The probability of developing neurotoxicity from selected cefepime dosing regimens

From: Cefepime dosing regimens in critically ill patients receiving continuous renal replacement therapy: a Monte Carlo simulation study

Cefepime dosing regimens Pre-dilution CVVH CVVHD
Effluent rate (mL/kg/h) 48-h trough probability ≥ 70 mg/L (%) Effluent rate (mL/kg/h) 48-h trough probability ≥ 70 mg/L (%)
1 g Q8H 10 0.18 10 0.04
15 0.00 15 0.00
20 0.00 20 0.00
25 0.00 25 0.00
35 0.00 35 0.00
1.75 g LD then 1.5 g Q8H 10 26.28 10 22.30
15 11.54 15 7.02
20 4.46 20 1.44
25 1.26 25 0.08
35 0.14 35 0.00
2 g LD then 1.5 g Q8H 10 26.04 10 21.7
15 13.36 15 7.40
20 5.12 20 0.98
25 1.50 25 0.06
35 0.08 35 0.00
1.75 g Q8H 10 45.44 10 41.30
15 29.14 15 22.24
20 16.84 20 7.82
25 7.96 25 1.94
35 1.22 35 0.04
2 g LD then 1.75 g Q8H 10 45.12 10 42.10
15 32.46 15 22.30
20 17.16 20 7.78
25 8.04 25 1.76
35 1.38 35 0.04
2 g Q8H 10 61.04 10 58.10
15 47.86 15 40.52
20 33.48 20 20.84
25 20.90 25 8.98
35 6.52 35 0.26
  1. CVVH continuous venovenous hemofiltration, CVVHD continuous venovenous hemodialysis, LD loading dose