Cefepime dosing regimen
|
Pre-dilution CVVH
|
CVVHD
|
---|
Effluent rates (mL/kg/h)
|
PTA (%)
|
Effluent rates (mL/kg/h)
|
PTA (%)
|
---|
MIC (mg/L)
|
MIC (mg/L)
|
---|
1
|
2
|
4
|
8
|
1
|
2
|
4
|
8
|
---|
250 mg Q8H
|
10
|
98.62
|
53.10
|
0.22
|
0.00
|
10
|
98.64
|
49.90
|
0.04
|
0.00
|
15
|
98.50
|
43.78
|
0.02
|
0.00
|
15
|
98.46
|
40.86
|
0.00
|
0.00
|
20
|
98.02
|
36.10
|
0.00
|
0.00
|
20
|
97.68
|
29.3
|
0.00
|
0.00
|
25
|
98.12
|
27.06
|
0.00
|
0.00
|
25
|
96.52
|
16.58
|
0.00
|
0.00
|
35
|
96.42
|
13.72
|
0.00
|
0.00
|
35
|
91.62
|
3.52
|
0.00
|
0.00
|
750 mg LD then 500 mg Q12H
|
10
|
100
|
95.24
|
20.88
|
0.00
|
10
|
99.98
|
94.42
|
17.96
|
0.00
|
15
|
100
|
91.44
|
11.00
|
0.00
|
15
|
99.98
|
89.06
|
8.12
|
0.00
|
20
|
99.96
|
86.86
|
5.12
|
0.00
|
20
|
99.88
|
80.80
|
1.54
|
0.00
|
25
|
99.80
|
81.28
|
1.64
|
0.00
|
25
|
99.52
|
71.46
|
0.14
|
0.00
|
35
|
99.38
|
66.48
|
0.10
|
0.00
|
35
|
98.72
|
42.06
|
0.00
|
0.00
|
1 g LD then 500 mg Q12H
|
10
|
100
|
98.42
|
38.36
|
0.00
|
10
|
100
|
98.02
|
33.30
|
0.00
|
15
|
99.96
|
96.88
|
25.34
|
0.00
|
15
|
99.98
|
95.60
|
18.52
|
0.00
|
20
|
99.96
|
94.00
|
14.22
|
0.00
|
20
|
99.86
|
90.26
|
7.24
|
0.00
|
25
|
99.90
|
90.24
|
6.86
|
0.00
|
25
|
99.84
|
83.04
|
1.96
|
0.00
|
35
|
99.74
|
80.30
|
1.00
|
0.00
|
35
|
99.08
|
58.44
|
0.04
|
0.00
|
750 mg Q12H
|
10
|
100
|
99.30
|
51.16
|
0.06
|
10
|
100
|
99.18
|
47.34
|
0.00
|
15
|
100
|
98.70
|
38.72
|
0.00
|
15
|
100
|
98.36
|
33.6
|
0.00
|
20
|
100
|
97.98
|
29.42
|
0.00
|
20
|
100
|
96.66
|
20.50
|
0.00
|
25
|
99.98
|
96.78
|
18.30
|
0.00
|
25
|
99.94
|
93.58
|
8.90
|
0.00
|
35
|
99.86
|
91.54
|
6.72
|
0.00
|
35
|
99.76
|
80.52
|
0.98
|
0.00
|
1 g Q12H
|
10
|
100
|
99.96
|
83.58
|
6.30
|
10
|
100
|
100
|
82.72
|
5.52
|
15
|
100
|
99.92
|
76.62
|
2.42
|
15
|
100
|
99.86
|
72.94
|
1.12
|
20
|
100
|
99.82
|
68.78
|
0.62
|
20
|
100
|
99.52
|
61.14
|
0.06
|
25
|
100
|
99.52
|
61.18
|
0.10
|
25
|
100
|
99.00
|
47.26
|
0.00
|
35
|
99.98
|
98.78
|
42.26
|
0.00
|
35
|
99.94
|
96.74
|
19.50
|
0.00
|
750 mg Q8H
|
10
|
100
|
99.98
|
92.48
|
19.38
|
10
|
100
|
99.98
|
92.08
|
16.34
|
15
|
100
|
99.98
|
90.78
|
12.92
|
15
|
100
|
100
|
87.92
|
8.86
|
20
|
100
|
99.94
|
86.92
|
6.56
|
20
|
100
|
99.96
|
83.70
|
3.14
|
25
|
100
|
99.98
|
83.92
|
0.26
|
25
|
100
|
99.96
|
77.50
|
0.56
|
35
|
100
|
99.98
|
73.96
|
0.52
|
35
|
100
|
99.88
|
54.20
|
0.00
|
1 g LD then 750 mg Q8H
|
10
|
100
|
100
|
96.12
|
28.10
|
10
|
100
|
100
|
95.98
|
26.90
|
15
|
100
|
100
|
94.92
|
18.86
|
15
|
100
|
100
|
94.26
|
14.62
|
20
|
100
|
100
|
93.08
|
11.82
|
20
|
100
|
99.98
|
91.14
|
7.50
|
25
|
100
|
100
|
90.62
|
7.00
|
25
|
100
|
100
|
84.68
|
1.98
|
35
|
100
|
99.98
|
82.84
|
1.30
|
35
|
100
|
99.92
|
66.64
|
0.02
|
1 g Q8H
|
10
|
100
|
100
|
98.58
|
54.02
|
10
|
100
|
100
|
98.60
|
51.60
|
15
|
100
|
100
|
98.20
|
45.68
|
15
|
100
|
100
|
98.14
|
40.96
|
20
|
100
|
100
|
97.96
|
35.56
|
20
|
100
|
100
|
97.54
|
29.68
|
25
|
100
|
100
|
97.96
|
29.46
|
25
|
100
|
100
|
96.50
|
18.22
|
35
|
100
|
100
|
96.56
|
13.88
|
35
|
100
|
100
|
91.62
|
3.58
|
1.75 g then 1.5 g Q 8 H
|
10
|
100
|
100
|
100
|
94.38
|
10
|
100
|
100
|
100
|
94.28
|
15
|
100
|
100
|
100
|
92.44
|
15
|
100
|
100
|
99.98
|
91.72
|
20
|
100
|
100
|
100
|
90.04
|
20
|
100
|
100
|
99.98
|
88.04
|
25
|
100
|
100
|
99.96
|
87.46
|
25
|
100
|
100
|
99.92
|
79.64
|
35
|
100
|
100
|
99.96
|
78.62
|
35
|
100
|
100
|
99.98
|
61.84
|
2 g LD then 1.5 g Q8H
|
10
|
100
|
100
|
100
|
96.04
|
10
|
100
|
100
|
100
|
95.3
|
15
|
100
|
100
|
100
|
95.24
|
15
|
100
|
100
|
100
|
94.36
|
20
|
100
|
100
|
99.98
|
93.26
|
20
|
100
|
100
|
99.98
|
90.66
|
25
|
100
|
100
|
100
|
90.50
|
25
|
100
|
100
|
99.98
|
84.60
|
35
|
100
|
100
|
100
|
82.96
|
35
|
100
|
100
|
99.96
|
66.70
|
1.75 g Q8H
|
10
|
100
|
100
|
100
|
96.94
|
10
|
100
|
100
|
100
|
96.22
|
15
|
100
|
100
|
100
|
96.34
|
15
|
100
|
100
|
100
|
95.70
|
20
|
100
|
100
|
100
|
95.42
|
20
|
100
|
100
|
100
|
94.64
|
25
|
100
|
100
|
100
|
94.58
|
25
|
100
|
100
|
100
|
92.00
|
35
|
100
|
100
|
100
|
89.48
|
35
|
100
|
100
|
99.98
|
77.76
|
2 g LD then 1.75 g Q8H
|
10
|
100
|
100
|
100
|
97.80
|
10
|
100
|
100
|
100
|
97.44
|
15
|
100
|
100
|
100
|
97.36
|
15
|
100
|
100
|
99.98
|
96.60
|
20
|
100
|
100
|
100
|
96.70
|
20
|
100
|
100
|
100
|
95.46
|
25
|
100
|
100
|
99.98
|
95.90
|
25
|
100
|
100
|
100
|
93.20
|
35
|
100
|
100
|
100
|
92.52
|
35
|
100
|
100
|
99.98
|
82.22
|
2 g Q8H
|
10
|
100
|
100
|
100
|
98.60
|
10
|
100
|
100
|
100
|
98.36
|
15
|
100
|
100
|
100
|
98.32
|
15
|
100
|
100
|
100
|
98.18
|
20
|
100
|
100
|
100
|
98.44
|
20
|
100
|
100
|
100
|
97.54
|
25
|
100
|
100
|
100
|
98.00
|
25
|
100
|
100
|
100
|
97.02
|
35
|
100
|
100
|
100
|
96.66
|
35
|
100
|
100
|
100
|
91.24
|
- PTA probability of target attainment, CVVH continuous venovenous hemofiltration, CVVHD continuous venovenous hemodialysis, LD loading dose