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Table 3 PTAs of all recommended cefepime dosing regimens for Gram-negative infections in two CRRT modalities with different effluent rates and various MICs

From: Cefepime dosing regimens in critically ill patients receiving continuous renal replacement therapy: a Monte Carlo simulation study

Cefepime dosing regimen Pre-dilution CVVH CVVHD
Effluent rates (mL/kg/h) PTA (%) Effluent rates (mL/kg/h) PTA (%)
MIC (mg/L) MIC (mg/L)
1 2 4 8 1 2 4 8
250 mg Q8H 10 98.62 53.10 0.22 0.00 10 98.64 49.90 0.04 0.00
15 98.50 43.78 0.02 0.00 15 98.46 40.86 0.00 0.00
20 98.02 36.10 0.00 0.00 20 97.68 29.3 0.00 0.00
25 98.12 27.06 0.00 0.00 25 96.52 16.58 0.00 0.00
35 96.42 13.72 0.00 0.00 35 91.62 3.52 0.00 0.00
750 mg LD then 500 mg Q12H 10 100 95.24 20.88 0.00 10 99.98 94.42 17.96 0.00
15 100 91.44 11.00 0.00 15 99.98 89.06 8.12 0.00
20 99.96 86.86 5.12 0.00 20 99.88 80.80 1.54 0.00
25 99.80 81.28 1.64 0.00 25 99.52 71.46 0.14 0.00
35 99.38 66.48 0.10 0.00 35 98.72 42.06 0.00 0.00
1 g LD then 500 mg Q12H 10 100 98.42 38.36 0.00 10 100 98.02 33.30 0.00
15 99.96 96.88 25.34 0.00 15 99.98 95.60 18.52 0.00
20 99.96 94.00 14.22 0.00 20 99.86 90.26 7.24 0.00
25 99.90 90.24 6.86 0.00 25 99.84 83.04 1.96 0.00
35 99.74 80.30 1.00 0.00 35 99.08 58.44 0.04 0.00
750 mg Q12H 10 100 99.30 51.16 0.06 10 100 99.18 47.34 0.00
15 100 98.70 38.72 0.00 15 100 98.36 33.6 0.00
20 100 97.98 29.42 0.00 20 100 96.66 20.50 0.00
25 99.98 96.78 18.30 0.00 25 99.94 93.58 8.90 0.00
35 99.86 91.54 6.72 0.00 35 99.76 80.52 0.98 0.00
1 g Q12H 10 100 99.96 83.58 6.30 10 100 100 82.72 5.52
15 100 99.92 76.62 2.42 15 100 99.86 72.94 1.12
20 100 99.82 68.78 0.62 20 100 99.52 61.14 0.06
25 100 99.52 61.18 0.10 25 100 99.00 47.26 0.00
35 99.98 98.78 42.26 0.00 35 99.94 96.74 19.50 0.00
750 mg Q8H 10 100 99.98 92.48 19.38 10 100 99.98 92.08 16.34
15 100 99.98 90.78 12.92 15 100 100 87.92 8.86
20 100 99.94 86.92 6.56 20 100 99.96 83.70 3.14
25 100 99.98 83.92 0.26 25 100 99.96 77.50 0.56
35 100 99.98 73.96 0.52 35 100 99.88 54.20 0.00
1 g LD then 750 mg Q8H 10 100 100 96.12 28.10 10 100 100 95.98 26.90
15 100 100 94.92 18.86 15 100 100 94.26 14.62
20 100 100 93.08 11.82 20 100 99.98 91.14 7.50
25 100 100 90.62 7.00 25 100 100 84.68 1.98
35 100 99.98 82.84 1.30 35 100 99.92 66.64 0.02
1 g Q8H 10 100 100 98.58 54.02 10 100 100 98.60 51.60
15 100 100 98.20 45.68 15 100 100 98.14 40.96
20 100 100 97.96 35.56 20 100 100 97.54 29.68
25 100 100 97.96 29.46 25 100 100 96.50 18.22
35 100 100 96.56 13.88 35 100 100 91.62 3.58
1.75 g then 1.5 g Q 8 H 10 100 100 100 94.38 10 100 100 100 94.28
15 100 100 100 92.44 15 100 100 99.98 91.72
20 100 100 100 90.04 20 100 100 99.98 88.04
25 100 100 99.96 87.46 25 100 100 99.92 79.64
35 100 100 99.96 78.62 35 100 100 99.98 61.84
2 g LD then 1.5 g Q8H 10 100 100 100 96.04 10 100 100 100 95.3
15 100 100 100 95.24 15 100 100 100 94.36
20 100 100 99.98 93.26 20 100 100 99.98 90.66
25 100 100 100 90.50 25 100 100 99.98 84.60
35 100 100 100 82.96 35 100 100 99.96 66.70
1.75 g Q8H 10 100 100 100 96.94 10 100 100 100 96.22
15 100 100 100 96.34 15 100 100 100 95.70
20 100 100 100 95.42 20 100 100 100 94.64
25 100 100 100 94.58 25 100 100 100 92.00
35 100 100 100 89.48 35 100 100 99.98 77.76
2 g LD then 1.75 g Q8H 10 100 100 100 97.80 10 100 100 100 97.44
15 100 100 100 97.36 15 100 100 99.98 96.60
20 100 100 100 96.70 20 100 100 100 95.46
25 100 100 99.98 95.90 25 100 100 100 93.20
35 100 100 100 92.52 35 100 100 99.98 82.22
2 g Q8H 10 100 100 100 98.60 10 100 100 100 98.36
15 100 100 100 98.32 15 100 100 100 98.18
20 100 100 100 98.44 20 100 100 100 97.54
25 100 100 100 98.00 25 100 100 100 97.02
35 100 100 100 96.66 35 100 100 100 91.24
  1. PTA probability of target attainment, CVVH continuous venovenous hemofiltration, CVVHD continuous venovenous hemodialysis, LD loading dose
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Journal of Intensive Care

ISSN: 2052-0492