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Table 2 Virtual patient characteristics compared with input pharmacokinetic parameters from published cefepime studies

From: Cefepime dosing regimens in critically ill patients receiving continuous renal replacement therapy: a Monte Carlo simulation study

Pharmacokinetic parameters Literature-based values
(mean ± SD (range limits))
(N = 37)
Simulation-based values
(mean ± SD (range limits))
(N = 5000)
Weight (kg) 60.72 ± 14.5 (40–230) 61.88 ± 13.77 (40.01–142.22)
Vd (L/kg) 0.5 ± 0.23 (0.21–1.11) 0.49 ± 0.19 (0.21–1.11)
CLNR (mL/min) 24.33 ± 11.25 (13–44) 24.21 ± 7.63 (13.00–43.99)
Free fraction 0.79 ± 0.09 (0.72–0.85) 0.78 ± 0.04 (0.72–0.85)
SC 0.79 ± 0.15 (0.47–0.92) 0.74 ± 0.10 (0.47–0.92)
SA 0.77 ± 0.09 (0.65–0.97) 0.78 ± 0.07 (0.65–0.97)