Table 2 Virtual patient characteristics compared with input pharmacokinetic parameters from published cefepime studies
Pharmacokinetic parameters | Literature-based values (mean ± SD (range limits)) (N = 37) | Simulation-based values (mean ± SD (range limits)) (N = 5000) |
|---|---|---|
Weight (kg) | 60.72 ± 14.5 (40–230) | 61.88 ± 13.77 (40.01–142.22) |
Vd (L/kg) | 0.5 ± 0.23 (0.21–1.11) | 0.49 ± 0.19 (0.21–1.11) |
CLNR (mL/min) | 24.33 ± 11.25 (13–44) | 24.21 ± 7.63 (13.00–43.99) |
Free fraction | 0.79 ± 0.09 (0.72–0.85) | 0.78 ± 0.04 (0.72–0.85) |
SC | 0.79 ± 0.15 (0.47–0.92) | 0.74 ± 0.10 (0.47–0.92) |
SA | 0.77 ± 0.09 (0.65–0.97) | 0.78 ± 0.07 (0.65–0.97) |