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Table 3 Final multivariate model—independent predictors of RBC transfusion

From: Hepcidin predicts response to IV iron therapy in patients admitted to the intensive care unit: a nested cohort study

Characteristic (n = 133) Coefficient (95% CI) Risk ratio (95% CI) p value
ICU admission type—trauma vs non trauma 0.833 (0.382–1.285) 2.30 (1.46–3.61) < 0.001
Haemoglobin > 80 g/L*—yes vs no − 0.99 (− 1.493 to − 0.493) 0.37 (0.22–0.61) < 0.001
Transferrin saturation—per 10% increase 0.237 (0.082–0.391) 1.27 (1.09–1.48) 0.003
Hepcidin—per 10 μg/ml increase 0.086 (0.030–0.142) 1.09 (1.03–1.15) 0.002
  1. CI confidence interval, ICU intensive care unit. Constant for model 0.088 (95% CI − 0.398–0.575)
  2. *Likelihood ratio test for significance of interaction between haemoglobin as a continuous variable and hepcidin concentration in predicting the risk of RBC transfusion p = 0.0462. For patients with a haemoglobin < 80 g/L, there was no significant association between hepcidin concentration and risk of RBC transfusion [RR 0.95 (95% CI 0.84–1.07), p = 0.387]