Hepcidin predicts response to IV iron therapy in patients admitted to the intensive care unit: a nested cohort study

Table 3 Final multivariate model—independent predictors of RBC transfusion

Characteristic (n = 133)	Coefficient (95% CI)	Risk ratio (95% CI)	p value
ICU admission type—trauma vs non trauma	0.833 (0.382–1.285)	2.30 (1.46–3.61)	< 0.001
Haemoglobin > 80 g/L^*—yes vs no	− 0.99 (− 1.493 to − 0.493)	0.37 (0.22–0.61)	< 0.001
Transferrin saturation—per 10% increase	0.237 (0.082–0.391)	1.27 (1.09–1.48)	0.003
Hepcidin—per 10 μg/ml increase	0.086 (0.030–0.142)	1.09 (1.03–1.15)	0.002

CI confidence interval, ICU intensive care unit. Constant for model 0.088 (95% CI − 0.398–0.575)
^*Likelihood ratio test for significance of interaction between haemoglobin as a continuous variable and hepcidin concentration in predicting the risk of RBC transfusion p = 0.0462. For patients with a haemoglobin < 80 g/L, there was no significant association between hepcidin concentration and risk of RBC transfusion [RR 0.95 (95% CI 0.84–1.07), p = 0.387]

ISSN: 2052-0492