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Table 2 Multiple logistic regression analysis adjusted for baseline patient characteristics and treatment (n = 2495)

From: Treatment of patients with sepsis in a closed intensive care unit is associated with improved survival: a nationwide observational study in Japan

 

Coefficient

Adj OR

95% CI

p value

Closed ICU

(Ref: open ICU)

0.463

1.589

1.276

1.827

0.001*

Type of ICU

(Ref: in-hospital general ICU)

      

 In-hospital surgical ICU

 

− 0.525

0.592

0.286

1.223

0.157

 Emergency ICU

 

0.101

1.106

0.9

1.36

0.338

Number of beds

(Continuous)

− 0.002

0.998

0.981

1.016

0.846

Blood culture

(Ref: no blood culture)

      

 Positive

 

− 0.785

0.456

0.279

0.746

0.002*

 Negative

 

− 0.407

0.666

0.419

1.059

0.086

Infection type

(Ref: unknown infection)

      

 Viral infection

 

0.447

1.563

0.48

5.085

0.458

 GNR infection

 

0.606

1.833

1.349

2.492

< 0.001*

 GPC infection

 

0.224

1.251

0.898

1.743

0.185

 Fungal infection

 

− 0.490

0.613

0.284

1.321

0.211

 Mixed infection

 

0.015

1.015

0.715

1.442

0.933

 Other infection

 

0.656

1.926

0.908

4.086

0.088

SOFA score

(Continuous)

− 0.133

0.876

0.845

0.908

< 0.001*

APACHE II score

(Continuous)

− 0.018

0.982

0.969

0.996

0.010*

SIRS score

(Continuous)

− 0.115

0.892

0.796

0.999

0.048*

Sex, female

(Ref: male)

0.373

1.451

1.171

1.799

< 0.001*

Age

(Continuous)

− 0.0238

0.976

0.969

0.985

< 0.001*

Body weight

(Continuous)

0.0193

1.020

1.011

1.028

< 0.001*

White blood cell count (× 103)

(Ref: 3.5~9)

      

 0~3.5

 

0.267

1.306

0.741

2.302

0.355

 9~

 

− 1.407

0.245

0.019

3.107

0.278

Hemoglobin

(Continuous)

0.049

1.05

1.006

1.097

0.026*

Platelet count (per 104)

(Continuous)

0.003

1.003

0.991

1.015

0.624

PT-INR

(Continuous)

− 0.0614

0.94

0.868

1.019

0.135

Co-morbidities

(Ref: no)

      

 Liver failure

 

− 0.724

0.485

0.288

0.817

0.007*

 Respiratory failure

 

− 0.434

0.648

0.404

1.038

0.071

 Cardiac failure

 

− 0.486

0.615

0.403

0.938

0.024*

 Renal failure

 

− 0.640

0.527

0.368

0.756

< 0.001*

 Immunological disorder

 

− 0.547

0.579

0.43

0.779

< 0.001*

 Hematologic disorder

(Ref: no)

− 0.355

0.701

0.516

0.952

0.023*

Red blood cell transfusion

(Continuous)

− 0.022

0.978

0.956

1.001

0.061

Fresh frozen plasma transfusion

(Continuous)

− 0.010

0.99

0.98

1.001

0.083

Platelet concentration transfusion

(Continuous)

0.002

1.002

0.996

1.008

0.529

Treatment for DIC

(Ref: no)

      

 Antithrombin III

 

0.185

1.203

0.938

1.544

0.145

 rhTM

 

0.294

1.341

1.043

1.725

0.022*

 Nafamostat

 

0.152

1.165

0.869

1.561

0.308

 Heparin

 

0.334

1.396

1.06

1.839

0.018*

 Warfarin

 

− 0.148

0.862

0.400

1.861

0.706

 Antiplatelet

 

0.318

1.374

0.679

2.778

0.377

 Others

 

0.303

1.354

0.318

5.768

0.682

Specific treatment

(Ref: no)

      

 Immunoglobulin

 

0.147

1.158

0.909

1.476

0.236

 Low-dose steroid

 

− 0.534

0.586

0.462

0.744

< 0.001*

 Renal replacement therapy

 

− 0.390

0.677

0.495

0.926

0.015*

 Renal replacement therapy not for renal indication

 

− 0.279

0.756

0.496

1.153

0.195

 Polymyxin B direct hemoperfusion

 

0.365

1.44

1.095

1.894

0.009*

 Plasma exchange

 

− 0.457

0.633

0.189

2.118

0.459

 Veno-arterial ECMO

 

− 2.475

0.084

0.021

0.341

< 0.001*

 Veno-venus ECMO

 

− 1.169

0.311

0.111

0.865

0.025*

 Ventilation support

 

− 0.815

0.443

0.339

 

0.578

< 0.001*

 Intra-aortic balloon pumping

 

0.993

2.699

0.467

15.608

0.268

  1. White blood cell count (× 103)
  2. adj OR adjusted odds ratio, CI confidence intervals, ICU intensive care unit, GNR gram-negative rods, GPC gram-positive coccus, SOFA score Sequential Organ Failure Assessment score, APACHE II score Acute Physiology and Chronic Health Evaluation II score, SIRS score systemic inflammatory response syndrome score, PT-INR prothrombin time-international normalized ratio, DIC disseminated intravascular coagulation, rhsTM recombinant human soluble thrombomodulin, ECMO extracorporeal
  3. *p < 0.05