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Table 2 Multiple logistic regression analysis adjusted for baseline patient characteristics and treatment (n = 2495)

From: Treatment of patients with sepsis in a closed intensive care unit is associated with improved survival: a nationwide observational study in Japan

  Coefficient Adj OR 95% CI p value
Closed ICU (Ref: open ICU) 0.463 1.589 1.276 1.827 0.001*
Type of ICU (Ref: in-hospital general ICU)       
 In-hospital surgical ICU   − 0.525 0.592 0.286 1.223 0.157
 Emergency ICU   0.101 1.106 0.9 1.36 0.338
Number of beds (Continuous) − 0.002 0.998 0.981 1.016 0.846
Blood culture (Ref: no blood culture)       
 Positive   − 0.785 0.456 0.279 0.746 0.002*
 Negative   − 0.407 0.666 0.419 1.059 0.086
Infection type (Ref: unknown infection)       
 Viral infection   0.447 1.563 0.48 5.085 0.458
 GNR infection   0.606 1.833 1.349 2.492 < 0.001*
 GPC infection   0.224 1.251 0.898 1.743 0.185
 Fungal infection   − 0.490 0.613 0.284 1.321 0.211
 Mixed infection   0.015 1.015 0.715 1.442 0.933
 Other infection   0.656 1.926 0.908 4.086 0.088
SOFA score (Continuous) − 0.133 0.876 0.845 0.908 < 0.001*
APACHE II score (Continuous) − 0.018 0.982 0.969 0.996 0.010*
SIRS score (Continuous) − 0.115 0.892 0.796 0.999 0.048*
Sex, female (Ref: male) 0.373 1.451 1.171 1.799 < 0.001*
Age (Continuous) − 0.0238 0.976 0.969 0.985 < 0.001*
Body weight (Continuous) 0.0193 1.020 1.011 1.028 < 0.001*
White blood cell count (× 103) (Ref: 3.5~9)       
 0~3.5   0.267 1.306 0.741 2.302 0.355
 9~   − 1.407 0.245 0.019 3.107 0.278
Hemoglobin (Continuous) 0.049 1.05 1.006 1.097 0.026*
Platelet count (per 104) (Continuous) 0.003 1.003 0.991 1.015 0.624
PT-INR (Continuous) − 0.0614 0.94 0.868 1.019 0.135
Co-morbidities (Ref: no)       
 Liver failure   − 0.724 0.485 0.288 0.817 0.007*
 Respiratory failure   − 0.434 0.648 0.404 1.038 0.071
 Cardiac failure   − 0.486 0.615 0.403 0.938 0.024*
 Renal failure   − 0.640 0.527 0.368 0.756 < 0.001*
 Immunological disorder   − 0.547 0.579 0.43 0.779 < 0.001*
 Hematologic disorder (Ref: no) − 0.355 0.701 0.516 0.952 0.023*
Red blood cell transfusion (Continuous) − 0.022 0.978 0.956 1.001 0.061
Fresh frozen plasma transfusion (Continuous) − 0.010 0.99 0.98 1.001 0.083
Platelet concentration transfusion (Continuous) 0.002 1.002 0.996 1.008 0.529
Treatment for DIC (Ref: no)       
 Antithrombin III   0.185 1.203 0.938 1.544 0.145
 rhTM   0.294 1.341 1.043 1.725 0.022*
 Nafamostat   0.152 1.165 0.869 1.561 0.308
 Heparin   0.334 1.396 1.06 1.839 0.018*
 Warfarin   − 0.148 0.862 0.400 1.861 0.706
 Antiplatelet   0.318 1.374 0.679 2.778 0.377
 Others   0.303 1.354 0.318 5.768 0.682
Specific treatment (Ref: no)       
 Immunoglobulin   0.147 1.158 0.909 1.476 0.236
 Low-dose steroid   − 0.534 0.586 0.462 0.744 < 0.001*
 Renal replacement therapy   − 0.390 0.677 0.495 0.926 0.015*
 Renal replacement therapy not for renal indication   − 0.279 0.756 0.496 1.153 0.195
 Polymyxin B direct hemoperfusion   0.365 1.44 1.095 1.894 0.009*
 Plasma exchange   − 0.457 0.633 0.189 2.118 0.459
 Veno-arterial ECMO   − 2.475 0.084 0.021 0.341 < 0.001*
 Veno-venus ECMO   − 1.169 0.311 0.111 0.865 0.025*
 Ventilation support   − 0.815 0.443 0.339   0.578 < 0.001*
 Intra-aortic balloon pumping   0.993 2.699 0.467 15.608 0.268
  1. White blood cell count (× 103)
  2. adj OR adjusted odds ratio, CI confidence intervals, ICU intensive care unit, GNR gram-negative rods, GPC gram-positive coccus, SOFA score Sequential Organ Failure Assessment score, APACHE II score Acute Physiology and Chronic Health Evaluation II score, SIRS score systemic inflammatory response syndrome score, PT-INR prothrombin time-international normalized ratio, DIC disseminated intravascular coagulation, rhsTM recombinant human soluble thrombomodulin, ECMO extracorporeal
  3. *p < 0.05