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Table 9 Urinary NGAL for early AKI diagnosis

From: The Japanese Clinical Practice Guideline for acute kidney injury 2016

Reference Author, year Cohort All case (n) AKI case AKI definition Urine sampling Cutoff Sensitivity Specificity AUC (95% CI)
n % sCr criteria UO criteria      
[123] Koyner et al. 2008 Cardiac surgery 72 34 47 Increase ≥ 25% in 3 days OR RRT N/A ICU admission 572 ng mgCr−1 0.61 0.73 0.71 (0.58–0.83)
[124] Tuladhar et al. 2009 Cardiac surgery 50 9 18 Increase ≥ 0.5 mg/dL in 48 h N/A 2 h postoperative 393 ng mmolCr−1 0.93 0.78 0.96 (0.90–1.00)
[138] Paarmann et al. 2013 Cardiac surgery 136 29 21 AKIN ≥ 1 N/A 6 h postoperative NR NR NR 0.61 (0.48–0.73)
[125] de Geus et al. 2011 ICU 632 171 27 RIFLE≥ R N/A ICU admission NR NR NR 0.80
[126] Wagener et al. 2006 Cardiac surgery 81 16 20 RIFLE ≥ R N/A 18 h postoperative 213 ng ml−1 0.73 0.78 0.80 (0.57–1.03)
[127] Wagener et al. 2008 Cardiac surgery 426 85 20 AKIN ≥ 1 N/A 18 h postoperative 65 ng ml−1 0.39 0.78 0.61 (0.54–0.68)
[128] Xin et al. 2008 Cardiac surgery 33 9 27 AKIN ≥ 1 AKIN ≥ 1 2 h postoperative 250 μg mmolCr−1 0.81 0.78 0.93
[129] Han et al. 2009 Cardiac surgery 90 36 40 Increase ≥ 0.5 mg/dL in 72 h N/A 3 h postoperative 456 ng mgCr−1 0.71 0.39 0.65 (0.54–0.76)
[130] Liangos et al. 2009 Cardiac surgery 103 13 13 Increase ≥ 50% in 72 h N/A 2 h post-CPB 166 ng mgCr−1 0.67 0.11 0.50 (0.33–0.68)
[131] Makris et al. 2009 ICU 31 11 35 RIFLE ≥ R N/A ICU admission 25 ng ml−1 0.91 0.95 0.98 (0.82–0.98)
[132] Heise et al. 2011 Cardiac surgery 50 38 76 AKIN ≥ 1 AKIN ≥ 1 6 h after ICU admission 16.8 μg L−1 0.82 0.78 0.77 (0.63–0.88)
[133] Ejaz et al. 2012 Cardiac surgery 100 27 27 AKIN ≥ 1 N/A 24 h after operation NR NR NR 0.62 (0.49–0.75)
[134] Sargenti et al. 2012 Cardiac surgery 52 15 29 AKIN ≥ 1 AKIN ≥ 1 4 h postoperative 55.2 μg gCr−1 0.55 0.73 0.71 (0.56–0.85)
[135] Liebetrau et al. 2013 Cardiac surgery 141 19 13 KDIGO ≥ 2 KDIGO ≥ 2 4 h postoperative NR NR NR 0.90 (0.81–0.99)
[136] Liu et al. 2013 Cardiac surgery 109 26 24 AKIN ≥ 1 N/A 2 h postoperative 33.73 ng mgCr−1 0.81 0.83 0.87 (0.78–0.97)
[137] Munir et al. 2013 Cardiac surgery 88 11 13 AKIN ≥ 1 AKIN ≥ 1 4 h postoperative 87 ng ml−1 0.91 0.99 0.91 (0.83–0.96)
  1. sCr serum creatinine, UO urine output, RRT renal replacement therapy, AUC area under the curve, 95% CI 95% confidence interval, NR not reported