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Table 4 Estimation of unknown baseline serum creatinine

From: The Japanese Clinical Practice Guideline for acute kidney injury 2016

Estimating baseline sCr method Characteristics in the diagnosis of AKI Reference
An estimated sCr determined by back-calculation using MDRD assuming a GFR of 75 mL/min/1.73 m2 Low specificity especially in CKD patients [18,19,20,21,22,23,24]
An estimated sCr determined by back-calculation using MDRD assuming a GFR of 100 mL/min/1.73 m2 Very high sensitivity and very low specificity [23]
The first admission sCr Low sensitivity [22]
A minimum inpatient sCr during the first 7 days Low specificity [22]
A minimum sCr during the first 7 days in the ICU Low specificity although tendency to underestimate the AKI stage [23]
An estimated sCr using multiple imputation methods such as sex, race, comorbidity (CKD, etc.), and a minimum inpatient sCr High specificity [19]
A minimum inpatient sCr   [11]
sCr = 1.0 mg/dL (male)/0.8 mg/dL (female)   [25]
  1. sCr serum creatinine, GFR glomerular filtration rate, CKD chronic kidney disease