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Table 10 Urinary L-FABP for early AKI diagnosis

From: The Japanese Clinical Practice Guideline for acute kidney injury 2016

Reference Author, year Cohort All case (n) AKI case AKI definition Urine sampling Cutoff Sensitivity Specificity AUC (95% CI)
n % sCr criteria UO criteria      
[146] Katagiri et al. 2012 Cardiac surgery 77 28 36 AKIN ≥ 1 No 12 h postoperative 51.6 ng ml−1 0.64 0.79 0.76 (0.62–0.86)
[141] Matsui et al. 2012 Cardiac surgery 85 48 56 AKIN ≥ 1 No 0 h postoperative 54.6 ng mgCr−1 0.77 0.92 0.86 (0.78–0.94)
[142] Doi et al. 2011 ICU 339 66 19 RIFLE ≥ R No Within 12 h ICU admission NR NR NR 0.80 (0.73–0.86)
[143] Matsui et al. 2011 ICU 26 14 54 AKIN ≥ 1 No ICU admission 44.1 μg gCr−1 0.86 1.00 0.95
[144] Cho et al. 2013 ICU 145 54 37 AKIN ≥ 1 No ICU admission 28.45 ng ml−1 0.72 0.76 0.78 (0.70–0.86)
[136] Liu et al. 2013 Cardiac surgery 109 26 24 AKIN ≥ 1 No 0 h postoperative 2226.5 μg gCr−1 0.85 0.82 0.84
[145] Nickolas et al. 2012 ICU 1635 62 4 RIFLE ≥ R No ED visit 12.9 ng ml−1 0.50 0.80 0.70 (0.65–0.76)
  1. sCr serum creatinine, UO urine output, RRT renal replacement therapy, AUC area under the curve, 95% CI 95% confidence interval, NR not reported