Table 5 Treatment with Mg in specific clinical settings

Hemodynamically stable patients with severe symptomatic hypomagnesemia

1–2 g [8–16 mEq] (4–8 mmol) MgSO4 given initially over 5–60 min followed by an infusion 4–8 g [32–64 mEq] (16–32 mmol) given slowly over 12–24 h.

–

[116, 128]

Torsades de pointes

2 g [16 mEq] (8 mmol) over 2–15 min followed by a continuous infusion.

The rate of Mg infusion depends on the clinical situation. Rapid infusion is associated with hypotension and asystole.

[116, 117]

Preeclampsia

4 g [32 mEq] (16 mmol) over 10–15 min followed by 1 g [8 mEq] (8 mmol) every following hours.

Evidence is conflicting and no consensus about the optimal Mg regimen exists. Suggested loading doses vary from 4 to 6 g (32–48 mEq; 16–24 mmol) and maintenance doses of 1–3 g (8–24 mEq; 4–12 mmol)/h.

[106]