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Table 2 Brain trauma guidelines for management of TBI patients

From: Seizure prophylaxis in the neuroscience intensive care unit

According to latest brain trauma foundation guidelines (2016) [75]

• Phenytoin is recommended for prevention of early PTS and it should be used for first 7 days after TBI [75].

• Phenytoin or valproate use is not recommended for prevention against late PTS [75].

• Given its safety profile levetiracetam could be a potential alternative to phenytoin for prophylaxis against early PTS. Presently there is not enough corroborative evidence to support its use over phenytoin [75].