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Table 1 Characteristics of ARDS patients included into the study

From: Intravenous immunoglobulin fails to improve ARDS in patients undergoing ECMO therapy

  ARDS patients without IgM-enriched IVIG treatment ARDS patients with IgM-enriched IVIG treatment P Value
Baseline Characteristics
 Number of patients 29 28  
 Age [years: median/ min/ max] 52/ 27/ 76 51.5/ 17/ 78  
 Female/male [number] 8/21 14/14  
 Duration of IVIG therapy 0 3  
 APACHE Score [median, min, max] 24/ 12/ 36 23/ 8.5/ 38 p=0.99
 SAPS Score [median, min, max] 40/ 18/ 70 45/ 14/ 77 p=0.99
Preexisting diseases
 Heart disease [number;%] 4; 14% 7; 25%  
 Diabetes mellitus [number;%] 3; 10% 6; 21%  
 Hypertension [number;%] 10; 35% 10; 36%  
 Immune suppression [number;%] 3; 10% 6; 21%  
 Malignancy [number;%] 3; 10% 6; 21%  
 Smoking [number;%] 10; 35% 5; 18%  
 Obesity [number;%] 9; 31% 8; 29%  
ARDS
 PaO2/FiO2 [median/ min/ max] 93/ 41/ 253 67/ 43/ 162 p=0.009
 PaO2/FiO2 ≤ 100 [number;%] 16; 55% 21; 75%  
 PaO2/FiO2 >100≤ 200 [number;%] 10; 35% 7; 25%  
 PaO2/FiO2 >200≤ 300 [number;%] 3; 10% 0  
 Duration of Ventilation [Hours; median, min, max] 399/ 20/ 1323 538/ 91/ 2472  
Infection
 Multiresistant pathogen [number; %] 0 2; 7%  
 Bacterial infection [number;%] 11; 38% 11; 39%  
 Legionella Pneumoniae [number;%] 1; 3% 3; 11%  
 Streptococcus pneumonia [number;%] 1; 3% 3; 11%  
 Pneumocystis jiroveci [number;%] 3; 10% 3; 11%  
 Other bacterial pathogen [number;%] 9; 31% 9; 32%  
 Fungal Infectiona [number;%] 6; 21% 7; 25%  
 Viral infection [number;%] 8; 28% 15; 54% p=0.0526
 Influenza [number;%] 3; 10% 10; 36% p=0.0295
 Herpes Virus [number;%] 6; 21% 9; 32%  
 Unknown pathogen [number;%] 9; 31% 3; 11%  
 Days of antibiotic therapy 12/ 2/ 40 18/ 3/ 65 p=0.0096
 Extrapulmonary Cause [number;%] 7; 24% 1; 4%  
ECMO therapy
 Duration [days; median/ min/ max] 14/ 1/ 45 18/ 4/ 78 p= 0.0582
 Days until reduction [median, min, max] 10/ 6/ 22 16/ 4/ 42 p= 0.1106
Extrapulmonary Organ Failure
 Days of Vasopressors [median, min, max] 12/ 2/ 27 13,5/ 2/ 24 p=0,1603
 Renal Replacement Therapy [number; %] 19; 66% 15; 54% p=0.36
  1. aFungal infection including all organ systems