Table 1 Characteristics of ARDS patients included into the study
From: Intravenous immunoglobulin fails to improve ARDS in patients undergoing ECMO therapy
ARDS patients without IgM-enriched IVIG treatment | ARDS patients with IgM-enriched IVIG treatment | P Value | |
|---|---|---|---|
Baseline Characteristics | |||
Number of patients | 29 | 28 | |
Age [years: median/ min/ max] | 52/ 27/ 76 | 51.5/ 17/ 78 | |
Female/male [number] | 8/21 | 14/14 | |
Duration of IVIG therapy | 0 | 3 | |
APACHE Score [median, min, max] | 24/ 12/ 36 | 23/ 8.5/ 38 | p=0.99 |
SAPS Score [median, min, max] | 40/ 18/ 70 | 45/ 14/ 77 | p=0.99 |
Preexisting diseases | |||
Heart disease [number;%] | 4; 14% | 7; 25% | |
Diabetes mellitus [number;%] | 3; 10% | 6; 21% | |
Hypertension [number;%] | 10; 35% | 10; 36% | |
Immune suppression [number;%] | 3; 10% | 6; 21% | |
Malignancy [number;%] | 3; 10% | 6; 21% | |
Smoking [number;%] | 10; 35% | 5; 18% | |
Obesity [number;%] | 9; 31% | 8; 29% | |
ARDS | |||
PaO2/FiO2 [median/ min/ max] | 93/ 41/ 253 | 67/ 43/ 162 | p=0.009 |
PaO2/FiO2 ≤ 100 [number;%] | 16; 55% | 21; 75% | |
PaO2/FiO2 >100≤ 200 [number;%] | 10; 35% | 7; 25% | |
PaO2/FiO2 >200≤ 300 [number;%] | 3; 10% | 0 | |
Duration of Ventilation [Hours; median, min, max] | 399/ 20/ 1323 | 538/ 91/ 2472 | |
Infection | |||
Multiresistant pathogen [number; %] | 0 | 2; 7% | |
Bacterial infection [number;%] | 11; 38% | 11; 39% | |
Legionella Pneumoniae [number;%] | 1; 3% | 3; 11% | |
Streptococcus pneumonia [number;%] | 1; 3% | 3; 11% | |
Pneumocystis jiroveci [number;%] | 3; 10% | 3; 11% | |
Other bacterial pathogen [number;%] | 9; 31% | 9; 32% | |
Fungal Infectiona [number;%] | 6; 21% | 7; 25% | |
Viral infection [number;%] | 8; 28% | 15; 54% | p=0.0526 |
Influenza [number;%] | 3; 10% | 10; 36% | p=0.0295 |
Herpes Virus [number;%] | 6; 21% | 9; 32% | |
Unknown pathogen [number;%] | 9; 31% | 3; 11% | |
Days of antibiotic therapy | 12/ 2/ 40 | 18/ 3/ 65 | p=0.0096 |
Extrapulmonary Cause [number;%] | 7; 24% | 1; 4% | |
ECMO therapy | |||
Duration [days; median/ min/ max] | 14/ 1/ 45 | 18/ 4/ 78 | p= 0.0582 |
Days until reduction [median, min, max] | 10/ 6/ 22 | 16/ 4/ 42 | p= 0.1106 |
Extrapulmonary Organ Failure | |||
Days of Vasopressors [median, min, max] | 12/ 2/ 27 | 13,5/ 2/ 24 | p=0,1603 |
Renal Replacement Therapy [number; %] | 19; 66% | 15; 54% | p=0.36 |