Systemic inflammatory response syndrome (SIRS) | Two or more of the following: • Temperature > 38 or < 36 °C • Heart rate > 90/min • Respiratory rate > 20/min • White blood cell count > 12 × 109 or < 4 × 109 |
Sepsis | SIRS and evidence of infection |
Severe sepsis | At least one sign of sepsis-associated organ dysfunction, hypoperfusion or hypotension, including lactate acidosis, oliguria, or acute alteration of mental state |
Septic shock | Severe sepsis with hypotension (systolic blood pressure < 90 mmHg or a reduction from baseline > 40 mmHg) refractory to adequate fluid resuscitations or need of inotropic drug |