Skip to main content

Table 2 Contribution of bone marrow aspiration to diagnosis and treatment

From: Contribution to diagnosis and treatment of bone marrow aspirate results in critically ill patients undergoing bone marrow aspiration: a retrospective study of 193 consecutive patients

Patient

Indication

Diagnostic contribution, N = 37

Therapeutic contribution, N = 14

1

b

Hemophagocytic syndrome

No

2 (a)

b

Maturation arrest of granulocyte precursors

No

3 (a)

c

Acute transformation of CMML

DFLST

4

d

Maturation arrest of granulocyte precursors

No

5 (a)

c

Maturation arrest of granulocyte precursors

No

6

c

No (normal marrow)

Addition of erythropoietin

7

c

Marginal zone lymphoma

No

8 (a)

c

No (normal marrow)

Addition of dasatinib

9 (a)

e

Maturation arrest of granulocyte precursors

Discontinuation of TMP/SMX

10

e

Hemophagocytic syndrome

No

11

c

Lymphocytic lymphoma

No

12

e

No (presence of phagocytic histiocytes)

Addition of etoposide

13

e

Myelodysplastic syndrome

No

14

b

Hemophagocytic syndrome

No

15

c

Diffuse large B cell lymphoma

Addition of COP (g)

16

c

Marginal zone lymphoma

No

17

d

Maturation arrest of granulocyte precursors

No

18 (a)

c

Acute monocytic leukemia

DFLST

19

c

Acute myeloid leukemia

DFLST

20

e

Hemophagocytic syndrome

No

21

e

Hemophagocytic syndrome

No

22

c

Myelodysplastic syndrome

No

23 (a)

c

Relapsed multiple myeloma

No

24

e

Hemophagocytic syndrome

No

25

d

Maturation arrest of granulocyte precursors

Discontinuation of tacrolimus

26

e

Hemophagocytic syndrome

No

27 (a)

c

Hemophagocytic syndrome

No

28

c

Multiple myeloma

No

29

e

Myelodysplastic syndrome

No

30

e

Myelodysplastic syndrome

No

31

b

Hemophagocytic syndrome

No

32

f

Diffuse large B cell lymphoma

Addition of COP (g)

33 (a)

c

Myelodysplastic syndrome

No

34

e

Hemophagocytic syndrome

Addition of etoposide

35 (a)

c

Hemophagocytic syndrome

No

36

e

Hemophagocytic syndrome

No

37

d

Maturation arrest of granulocyte precursors

Addition of lenogastrim

38

d

Maturation arrest of granulocyte precursors

Discontinuation of amoxicillin

39

d

Maturation arrest of granulocyte precursors

Addition of lenogastrim

40 (a)

c

Maturation arrest of granulocyte precursors

No

  1. In patients 6, 8, and 12, BMA did not contribute to diagnosis but contributed to treatment
  2. a, hematological malignancy or cancer already known upon ICU admission; b, suspicion of hemophagocytic lymphohistiocytosis; c, suspicion of hematological malignancy; d, agranulocytosis; e, thrombocytopenia; f, suspected cancer that has spread to the bone marrow; g, ultimately followed by DFLST; CMML, chronic myelomonocytic leukemia; COP, cyclophosphamide, vincristine, prednisone; DFLST, decision to forego life-sustaining treatment; TMP/SMX, trimethoprim/sulfamethoxazole