Contribution to diagnosis and treatment of bone marrow aspirate results in critically ill patients undergoing bone marrow aspiration: a retrospective study of 193 consecutive patients

Table 1 Characteristics of the study population

Patients	n = 193
Baseline characteristics
Age (years)^a	66 ± 14
Gender ratio (male/female)	1.5
Body mass index^a	26 ± 7
SOFA on ICU admission^b	7 [5–11]
SAPS II on ICU admission^b	60 [40–72]
McCabe score 2^c,d	26 (13)
Hematological malignancy or cancer previously diagnosed^c	33 (17)
Nonmalignant hematological abnormality previously diagnosed^c,e	14 (7)
Reason for ICU admission^c
Acute respiratory failure	67 (35)
Severe sepsis/septic shock	50 (26)
Acute renal failure and metabolic disorder	28 (14)
Coma	19 (10)
Other^f	29 (15)
Vitamin B12 deficiency^c,g,h	2 (2)
Vitamin B9 deficiency^c,g,i	25 (36)
Days from admission to biopsy (days)^b	5 [3–8]
Characteristics on the day of BMA
BMA at the sternal site^c	155 (80)
BMA at the iliac crest site	38 (20)
Sepsis^cj	124 (64)
Adenopathy^c,j	14 (7)
Splenomegaly^c	7 (4)
Monoclonal gammapathy^c	18 (9)
Anticoagulant agent^c,k	129 (67)
Prophylactic anticoagulation^c	87 (45)
Therapeutic anticoagulation^c	42 (22)
Antiplatelet agent^c	31 (16)
Proton-pump inhibitor agent^c	40 (21)
Anti-infectious agent with potential hematoxcicity^c	146 (76)
Other agent with potential hematoxcicity^c	76 (39)
Pre-BMA HScore	62 [24–96]
SOFA^c	8 [5–11]
Invasive ventilation^c	52 (27)
Vasopressors^c	90 (47)
Renal replacement therapy	31 (16)
ICU length of stay^b	14 [7–29]
ICU mortality^c	59 (31)
Hospital mortality^c	78 (40)

ICU intensive care unit; PreBMA HScore, SAPS II simplified acute physiology score, SOFA Sequential Organ Failure Assessment score
^aMean ± SD
^bMedian [interquartile range]
^cNumber (percentage)
^dFatal outcome within 12 months
^eThrombocytopenia (n = 5), monoclonal gammopathy of undetermined significance (n = 3), polycythemia (n = 2), auto-immune cytopenia (n = 4)
^fCardiac arrest (N = 9), other shock (N = 8), thrombotic microangiopathy (N = 7), post-surgery surveillance (N = 5)
^gBlood samples drawn between admission and BMA
^hEighty-two missing data
ⁱOne hundred twenty-four missing data
^jIn 48 patients, sepsis was unresolved since ICU admission
^kUnfractionated heparin (N = 44), low-molecular-weight heparin (N = 78), danaparoid (N = 7)

ISSN: 2052-0492