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Table 1 Characteristics of the study population

From: Contribution to diagnosis and treatment of bone marrow aspirate results in critically ill patients undergoing bone marrow aspiration: a retrospective study of 193 consecutive patients

Patients n = 193
Baseline characteristics  
 Age (years)a 66 ± 14
 Gender ratio (male/female) 1.5
 Body mass indexa 26 ± 7
 SOFA on ICU admissionb 7 [5–11]
 SAPS II on ICU admissionb 60 [40–72]
 McCabe score 2c,d 26 (13)
 Hematological malignancy or cancer previously diagnosedc 33 (17)
 Nonmalignant hematological abnormality previously diagnosedc,e 14 (7)
 Reason for ICU admissionc  
 Acute respiratory failure 67 (35)
 Severe sepsis/septic shock 50 (26)
 Acute renal failure and metabolic disorder 28 (14)
 Coma 19 (10)
 Otherf 29 (15)
Vitamin B12 deficiencyc,g,h 2 (2)
Vitamin B9 deficiencyc,g,i 25 (36)
Days from admission to biopsy (days)b 5 [3–8]
Characteristics on the day of BMA  
 BMA at the sternal sitec 155 (80)
 BMA at the iliac crest site 38 (20)
 Sepsiscj 124 (64)
 Adenopathyc,j 14 (7)
 Splenomegalyc 7 (4)
 Monoclonal gammapathyc 18 (9)
 Anticoagulant agentc,k 129 (67)
 Prophylactic anticoagulationc 87 (45)
 Therapeutic anticoagulationc 42 (22)
 Antiplatelet agentc 31 (16)
 Proton-pump inhibitor agentc 40 (21)
 Anti-infectious agent with potential hematoxcicityc 146 (76)
 Other agent with potential hematoxcicityc 76 (39)
 Pre-BMA HScore 62 [24–96]
 SOFAc 8 [5–11]
 Invasive ventilationc 52 (27)
 Vasopressorsc 90 (47)
 Renal replacement therapy 31 (16)
ICU length of stayb 14 [7–29]
ICU mortalityc 59 (31)
Hospital mortalityc 78 (40)
  1. ICU intensive care unit; PreBMA HScore, SAPS II simplified acute physiology score, SOFA Sequential Organ Failure Assessment score
  2. aMean ± SD
  3. bMedian [interquartile range]
  4. cNumber (percentage)
  5. dFatal outcome within 12 months
  6. eThrombocytopenia (n = 5), monoclonal gammopathy of undetermined significance (n = 3), polycythemia (n = 2), auto-immune cytopenia (n = 4)
  7. fCardiac arrest (N = 9), other shock (N = 8), thrombotic microangiopathy (N = 7), post-surgery surveillance (N = 5)
  8. gBlood samples drawn between admission and BMA
  9. hEighty-two missing data
  10. iOne hundred twenty-four missing data
  11. jIn 48 patients, sepsis was unresolved since ICU admission
  12. kUnfractionated heparin (N = 44), low-molecular-weight heparin (N = 78), danaparoid (N = 7)