Baseline characteristics
| |
Age (years)a
|
66 ± 14
|
Gender ratio (male/female)
|
1.5
|
Body mass indexa
|
26 ± 7
|
SOFA on ICU admissionb
|
7 [5–11]
|
SAPS II on ICU admissionb
|
60 [40–72]
|
McCabe score 2c,d
|
26 (13)
|
Hematological malignancy or cancer previously diagnosedc
|
33 (17)
|
Nonmalignant hematological abnormality previously diagnosedc,e
|
14 (7)
|
Reason for ICU admissionc
| |
Acute respiratory failure
|
67 (35)
|
Severe sepsis/septic shock
|
50 (26)
|
Acute renal failure and metabolic disorder
|
28 (14)
|
Coma
|
19 (10)
|
Otherf
|
29 (15)
|
Vitamin B12 deficiencyc,g,h
|
2 (2)
|
Vitamin B9 deficiencyc,g,i
|
25 (36)
|
Days from admission to biopsy (days)b
|
5 [3–8]
|
Characteristics on the day of BMA
| |
BMA at the sternal sitec
|
155 (80)
|
BMA at the iliac crest site
|
38 (20)
|
Sepsiscj
|
124 (64)
|
Adenopathyc,j
|
14 (7)
|
Splenomegalyc
|
7 (4)
|
Monoclonal gammapathyc
|
18 (9)
|
Anticoagulant agentc,k
|
129 (67)
|
Prophylactic anticoagulationc
|
87 (45)
|
Therapeutic anticoagulationc
|
42 (22)
|
Antiplatelet agentc
|
31 (16)
|
Proton-pump inhibitor agentc
|
40 (21)
|
Anti-infectious agent with potential hematoxcicityc
|
146 (76)
|
Other agent with potential hematoxcicityc
|
76 (39)
|
Pre-BMA HScore
|
62 [24–96]
|
SOFAc
|
8 [5–11]
|
Invasive ventilationc
|
52 (27)
|
Vasopressorsc
|
90 (47)
|
Renal replacement therapy
|
31 (16)
|
ICU length of stayb
|
14 [7–29]
|
ICU mortalityc
|
59 (31)
|
Hospital mortalityc
|
78 (40)
|