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Table 2 Comparison of sepsis biomarkers and coagulation/fibrinolysis markers

From: Usefulness of plasminogen activator inhibitor-1 as a predictive marker of mortality in sepsis

  Total
n = 186
Non-survivors
n = 36
Survivors
n = 150
P value
CRP (mg/dl) 12 (5–20) 15 (9–21) 12 (4–20) 0.21
PCT (ng/ml) 7 (1–42) 18 (2–89) 6 (1–33) <0.05
PSEP (pg/ml) 839 (440–1597) 905 (546–1811) 815 (422–1562) 0.12
Platelet count (×104/μl) 14.8 (8.6–23.0) 16.6 (5.8–25.3) 14.4 (9.0–22.3) 0.81
PT-INR 1.3 (1.2–1.6) 1.5 (1.3–2.1) 1.3 (1.2–1.5) <0.05
APTT (s) 35 (30–42) 39 (33–45) 34 (30–41) <0.05
AT (%) 70 (56–87) 63 (48–77) 73 (58–87) <0.05
D-dimer (μg/ml) 6.8 (2.9–15.7) 8.4 (3.3–18.2) 6.7 (2.8–14.6) 0.27
TAT (ng/ml) 6.9 (3.7–16.5) 8.9 (5.5–34.8) 6.5 (3.2–13.0) <0.05
PIC (μg/ml) 1.7 (1.0–3.3) 1.5 (0.8–3.2) 1.7 (1.1–3.4) 0.19
PC (%) 47 (33–70) 38 (26–56) 52 (34–70) <0.01
TM (U/ml) 33 (23–47) 40 (25–52) 32 (23–45) 0.12
SF (μg/ml) 21 (12–62) 45 (17–80) 20 (12–43) <0.01
PAI-1 (ng/ml) 66 (29–191) 154 (73–527) 51 (26–154) <0.01
  1. Data are presented as median (interquartile range)
  2. CRP C-reactive protein, PCT procalcitonin, PSEP presepsin, PT-INR prothrombin time-international normalized ratio, APTT activated partial thromboplastin time, AT antithrombin, TAT thrombin-antithrombin complex, PIC plasmin α2-plasmin inhibitor complex, PC protein C, TM thrombomodulin, SF soluble fibrin, PAI-1 plasminogen activator inhibitor-1