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Table 2 Comparison of sepsis biomarkers and coagulation/fibrinolysis markers

From: Usefulness of plasminogen activator inhibitor-1 as a predictive marker of mortality in sepsis

 

Total

n = 186

Non-survivors

n = 36

Survivors

n = 150

P value

CRP (mg/dl)

12 (5–20)

15 (9–21)

12 (4–20)

0.21

PCT (ng/ml)

7 (1–42)

18 (2–89)

6 (1–33)

<0.05

PSEP (pg/ml)

839 (440–1597)

905 (546–1811)

815 (422–1562)

0.12

Platelet count (×104/μl)

14.8 (8.6–23.0)

16.6 (5.8–25.3)

14.4 (9.0–22.3)

0.81

PT-INR

1.3 (1.2–1.6)

1.5 (1.3–2.1)

1.3 (1.2–1.5)

<0.05

APTT (s)

35 (30–42)

39 (33–45)

34 (30–41)

<0.05

AT (%)

70 (56–87)

63 (48–77)

73 (58–87)

<0.05

D-dimer (μg/ml)

6.8 (2.9–15.7)

8.4 (3.3–18.2)

6.7 (2.8–14.6)

0.27

TAT (ng/ml)

6.9 (3.7–16.5)

8.9 (5.5–34.8)

6.5 (3.2–13.0)

<0.05

PIC (μg/ml)

1.7 (1.0–3.3)

1.5 (0.8–3.2)

1.7 (1.1–3.4)

0.19

PC (%)

47 (33–70)

38 (26–56)

52 (34–70)

<0.01

TM (U/ml)

33 (23–47)

40 (25–52)

32 (23–45)

0.12

SF (μg/ml)

21 (12–62)

45 (17–80)

20 (12–43)

<0.01

PAI-1 (ng/ml)

66 (29–191)

154 (73–527)

51 (26–154)

<0.01

  1. Data are presented as median (interquartile range)
  2. CRP C-reactive protein, PCT procalcitonin, PSEP presepsin, PT-INR prothrombin time-international normalized ratio, APTT activated partial thromboplastin time, AT antithrombin, TAT thrombin-antithrombin complex, PIC plasmin α2-plasmin inhibitor complex, PC protein C, TM thrombomodulin, SF soluble fibrin, PAI-1 plasminogen activator inhibitor-1