Table 1 Summary of included studies and extubation success based on cough peak expiratory flow thresholds
Authors/year | Extubation results | CPEF, mean (L/min) | CPEF threshold established (L/min) | Predictive power |
|---|---|---|---|---|
Bach et al. 1996 [13] | 43/58 success 15/58 failure | 278.0 101.0 | 160.0 | N/A |
Smina et al. 2003 [17] | 102/115 success 13/115 failure | 81.9 64.2 | 60.0 | Extubation failure RR 5.1 (95% CI 1.7–15.4) |
Salam et al. 2004 [18] | 74/88 success 14/88 failure | 79.7 58.1 | 60.0 | Extubation failure RR 4.8 (95% CI 1.4–16.2) |
Beuret et al. 2009 [19] | 116/130 success 14/130 failure | 63.6 36.3 | 35.0 | Extubation failure RR 6.9 (95% CI 2–24) |
Su et al. 2010 [22] | 118/150 success 32/150 failure | 74.0 42.0 | 58.5 | Extubation success RR 0.95 (95% CI 0.93–0.98) |
Smailes et al. 2013 [20] | 10/125 success 17/125 failure | 125.8 74.2 | 60.0 | Extubation failure RR 9.1 (95% CI 4–20.6) |
Duan et al. 2014 [23] | 95/115 success 20/115 failure | 81.3 51.3 | 62.4 | Predicting re-intubation Sensitivity 85.0% Specificity 64.2% |
Kutchak et al. 2015 [21] | 90/135 success 45/135 failure | 115.3 75.8 | 80.0 | Extubation success RR 0.64 (95% CI 0.51–0.83) |
Duan et al. 2015 [16] | 158/186 success 28/186 failure | 74.3 51.7 | Semiquantitative cough strength score (SCSS) SCSS 5 (113.7 L/min) SCSS 4 (79.0 L/min) SCSS 3 (57.5 L/min) SCSS 2 (44.7 L/min) SCSS 1 (39.5 L/min) SCSS 0 (38.4 L/min) | Extubation failure RR 1.0 (reference) RR 3.2 (95% CI 0.7–15.7) RR 4.0 (95% CI 0.8–19.1) RR 4.7 (95% CI 1.0–22.0) RR 6.1 (95% CI 1.3–29.0) RR 7.2 (95% CI 1.5–33.8) |