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Table 1 Summary of included studies and extubation success based on cough peak expiratory flow thresholds

From: Evaluation of cough peak expiratory flow as a predictor of successful mechanical ventilation discontinuation: a narrative review of the literature

Authors/year Extubation results CPEF, mean (L/min) CPEF threshold established (L/min) Predictive power
Bach et al. 1996 [13] 43/58 success
15/58 failure
278.0
101.0
160.0 N/A
Smina et al. 2003 [17] 102/115 success
13/115 failure
81.9
64.2
60.0 Extubation failure
RR 5.1 (95% CI 1.7–15.4)
Salam et al. 2004 [18] 74/88 success
14/88 failure
79.7
58.1
60.0 Extubation failure
RR 4.8 (95% CI 1.4–16.2)
Beuret et al. 2009 [19] 116/130 success
14/130 failure
63.6
36.3
35.0 Extubation failure
RR 6.9 (95% CI 2–24)
Su et al. 2010 [22] 118/150 success
32/150 failure
74.0
42.0
58.5 Extubation success
RR 0.95 (95% CI 0.93–0.98)
Smailes et al. 2013 [20] 10/125 success
17/125 failure
125.8
74.2
60.0 Extubation failure
RR 9.1 (95% CI 4–20.6)
Duan et al. 2014 [23] 95/115 success
20/115 failure
81.3
51.3
62.4 Predicting re-intubation
Sensitivity 85.0%
Specificity 64.2%
Kutchak et al. 2015 [21] 90/135 success
45/135 failure
115.3
75.8
80.0 Extubation success
RR 0.64 (95% CI 0.51–0.83)
Duan et al. 2015 [16] 158/186 success
28/186 failure
74.3
51.7
Semiquantitative cough strength score (SCSS)
SCSS 5 (113.7 L/min)
SCSS 4 (79.0 L/min)
SCSS 3 (57.5 L/min)
SCSS 2 (44.7 L/min)
SCSS 1 (39.5 L/min)
SCSS 0 (38.4 L/min)
Extubation failure
RR 1.0 (reference)
RR 3.2 (95% CI 0.7–15.7)
RR 4.0 (95% CI 0.8–19.1)
RR 4.7 (95% CI 1.0–22.0)
RR 6.1 (95% CI 1.3–29.0)
RR 7.2 (95% CI 1.5–33.8)