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Table 1 á…Ÿ

From: The role of contact system in septic shock: the next target? An overview of the current evidence

Author, year of publication

Subject studied

Intervention

Main outcomes analyzed

Results

Reported drug adverse effects

Pixley et al. 1993 [13]

Baboons injected with Escherichia coli

C6B7, an antibody to FXII

Mortality, reversible hypotension, and DIC

Null hypothesis rejected for mortality and reversible hypotension, but not DIC

None reported

Ridings et al, 1995 [14]

Porcine models injected with Pseudomonas aeruginosa

NPC 17731, a B2R antagonist

SAP, SVRI, CI arterial pH

Significant improvement in SAP, SVRI, and artery pH comparing to septic control, but not in CI

None reported

Shin et al, 1996 [15]

Rats injected with Pseudomonas elastase

Soybean trypsin inhibitor (a kallikrein inhibitor)

Hypotension

Hypotension response completely abolished in treatment group

None reported

Fein et al. 1997 [16]

Humans with sepsis and evidence of dysfuntion of two or more organs

Deltaband, a B2R antagonist

Mortality and APACHE III score

No difference in overall mortality or APACHE scores, but significant improvement among gram-negative sepsis patients

No increase in adverse effects compared to placebo. No other safety concern noted

Caliezi et al. 2002 [19]

Humans with severe sepsis or septic shock

C1-inhibitor

Mortality and organ dysfunction

No improvement in mortality, but significant attenuation in the degree of renal dysfunction

None reported

Barratt-Due et al. 2011[20]

Porcine models injected with Neisseria meningitidis

Icatiband, aB2R antagonist

Mortality and physiological parameters

No significant difference between the studied groups

None reported

Murugesan et al. 2016 [21]

Rats with polymicrobial severe sepsis (induced by cecal ligation and puncture)

BI113823, a B1R antagonist

Mortality and physiological parameters

Significant improvement in overall mortality and many physiological parameters

None reported

  1. Summary of studies which used pharmacological interventions targeting the contact system and their results. [FXII Factor XII, DIC disseminated intravascular coagulation, SAP systemic arterial pressure, SVRI systemic vascular resistance index, CI cardiac index, B2R bradykinin-2-receptor, B1R bradykinin-1-receptor]