From: The role of contact system in septic shock: the next target? An overview of the current evidence
Author, year of publication | Subject studied | Intervention | Main outcomes analyzed | Results | Reported drug adverse effects |
---|---|---|---|---|---|
Pixley et al. 1993 [13] | Baboons injected with Escherichia coli | C6B7, an antibody to FXII | Mortality, reversible hypotension, and DIC | Null hypothesis rejected for mortality and reversible hypotension, but not DIC | None reported |
Ridings et al, 1995 [14] | Porcine models injected with Pseudomonas aeruginosa | NPC 17731, a B2R antagonist | SAP, SVRI, CI arterial pH | Significant improvement in SAP, SVRI, and artery pH comparing to septic control, but not in CI | None reported |
Shin et al, 1996 [15] | Rats injected with Pseudomonas elastase | Soybean trypsin inhibitor (a kallikrein inhibitor) | Hypotension | Hypotension response completely abolished in treatment group | None reported |
Fein et al. 1997 [16] | Humans with sepsis and evidence of dysfuntion of two or more organs | Deltaband, a B2R antagonist | Mortality and APACHE III score | No difference in overall mortality or APACHE scores, but significant improvement among gram-negative sepsis patients | No increase in adverse effects compared to placebo. No other safety concern noted |
Caliezi et al. 2002 [19] | Humans with severe sepsis or septic shock | C1-inhibitor | Mortality and organ dysfunction | No improvement in mortality, but significant attenuation in the degree of renal dysfunction | None reported |
Barratt-Due et al. 2011[20] | Porcine models injected with Neisseria meningitidis | Icatiband, aB2R antagonist | Mortality and physiological parameters | No significant difference between the studied groups | None reported |
Murugesan et al. 2016 [21] | Rats with polymicrobial severe sepsis (induced by cecal ligation and puncture) | BI113823, a B1R antagonist | Mortality and physiological parameters | Significant improvement in overall mortality and many physiological parameters | None reported |