Association between recurrence of acute kidney injury and mortality in intensive care unit patients with severe sepsis

Table 2 Hazard ratios for in-ICU AKI existence, in relation to mortality

	Vital status (intra-hospital)					Vital status (90-day)					Vital status (end of follow-up)
	Survival (N)	Death (N)	HR	(95% CI)		Survival (N)	Death (N)	HR	(95% CI)		Survival (N)	Death (N)	HR	(95% CI)
Including patients without AKI (N = 400)	298	102				290	110				212	188
No AKI (n = 69)	62	7	1	–		61	8	1	–		47	22	1	–
AKI = 1 (n = 252)	192	60	1.68^a	0.74	3.82	188	64	1.54^a	0.71	3.34	139	113	1.00^a	0.61	1.63
AKI ≥2 (n = 79)	44	35	2.73^a	1.15	6.51	41	38	2.57^a	1.13	5.83	26	53	1.61^a	0.93	2.77
Linear p trend			0.006					0.005					0.021
Excluding patients without AKI (N = 331)	236	95				229	102				165	166
AKI = 1 (n = 252)	192	60	1	–		188	64	1	–		139	113	1	–
AKI ≥2 (n = 79)	44	35	2.48^b	1.47	4.19	41	38	2.54^b	1.55	4.16	26	53	1.97^b	1.36	2.84

^aHR = hazard ratio adjusted for sex, age, mechanical ventilation necessity, APACHE score, and baseline estimated glomerular filtration rate (GFR)
^bHR = hazard ratio adjusted for sex, age, mechanical ventilation necessity, APACHE score, baseline estimated GFR, complete recovery and KDIGO stage