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Table 2 ICH vs. non-ICH cohorts: demographics, pre-admission morbidity, pre-cannulation SOFA score, ECMO mode, and indication

From: Predictors of intracranial hemorrhage in adult patients on extracorporeal membrane oxygenation: an observational cohort study

Variable

ICH cohort (n = 54)

Non-ICH cohort (n = 199)

p value

Demographics

 Age (years)

51.5 (40–61)

50 (32–60)

0.158

 Male sex

35 (65%)

127 (64%)

1.000

Pre-admission morbidity

 Hypertension

9 (17%)

36 (18%)

0.967

 Insulin-dependent diabetes mellitus

5 (9%)

22 (11%)

0.896

 Chronic renal disease

2 (4%)

1 (1%)

0.116

 Antithrombotic therapy

7 (13%)

7 (4%)

0.018

 Charlson comorbidity index

0 (0–1)

0 (0–1)

0.373

Pre-cannulation SOFA score

 Total

14 (10.8–16) (26 missing, 48%)

13 (10–15) (106 missing, 53%)

0.443

 Respiration

4 (4–4) (25 missing, 46%)

4 (4–4) (95 missing, 48%)

0.340

 Coagulation

2 (0–3) (26 missing, 48%)

1 (0–2) (100 missing, 50%)

0.015

 Liver

1 (0–2) (26 missing, 48%)

1 (0–2) (102 missing, 51%)

0.960

 Cardiovascular

4 (3–4) (25 missing, 46%)

4 (3–4) (95 missing, 48%)

0.742

 Neurological

1 (0–2) (25 missing, 46%)

1 (0–2) (98 missing, 49%)

0.726

 Renal

1.5 (1–4) (26 missing, 48%)

1 (0–4) (101 missing, 51%)

0.606

ECMO Indication

 Pulmonary

48 (89%)

176 (88%)

 

 Cardiac

2 (4%)

17 (9%)

 

 ECPR

4 (7%)

6 (3%)

 

ECMO mode

 Venovenous

31 (57%)

130 (65%)

0.361

 Venoarterial

23 (43%)

69 (35%)

0.361

  1. Values are expressed as median (interquartile range) or numbers (proportion)
  2. Italicized text in the p value column indicates a statistically significant correlation (p < 0.05)
  3. Pulmonary indications included pneumonia (n = 102), sepsis (n = 78), respiratory failure (n = 18), ARDS (n = 17), trauma (n = 6), and drowning (n = 3). Cardiac indications included cardiogenic shock (n = 18) and pulmonary embolism (n = 1)
  4. Abbreviations: SOFA Sepsis-related Organ Failure Assessment (also known as Severity Organ Failure Assessment), ECMO extracorporeal membrane oxygenation, ICH intracranial hemorrhage, ECPR extracorporeal cardiopulmonary resuscitation