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Table 4 Uni- and multivariate Cox regression analyses for CT-proET-1 levels at ICU admission to predict overall mortality

From: C-terminal proendothelin-1 (CT-proET-1) is associated with organ failure and predicts mortality in critically ill patients

  Unadjusted HR (95%-CI) p Adjusted HR (95%-CI) p
CT-proET-1 > 74 pmol/L 2.731 (1.535–4.858) 0.001 2.193 (1.209–3.975) 0.01
Creatinine (per mg/dL) 1.034 (0.946–1.129) 0.461 n.s.
CRP (per mg/L) 1.002 (0.999–1.006) 0.129 n.s.
Bilirubin (per mg/dL) 1.16 (0.935–1.16) 0.176 n.s.
Prothrombin time (per %) 0.99 (0.979–1) 0.052 n.s.
Lactate (per mmol/L) 1.082 (0.949–1.234) 0.239 n.s.
Age (per year) 1.036 (1.014–1.059) <0.001 1.028 (1.005–1.051) 0.04
  1. Variables with a univariate p < 0.25 were included in the multivariate model
  2. Abbreviations: 95%-CI 95% confidence-interval, CRP C-reactive protein, CT-proET-1 C-terminal proendothelin-1, n.s. not significant