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Table 3 Uni- and multivariate Cox regression analyses for CT-proET-1 levels at ICU admission to predict ICU mortality

From: C-terminal proendothelin-1 (CT-proET-1) is associated with organ failure and predicts mortality in critically ill patients

  Unadjusted HR (95%-CI) p Adjusted HR (95%-CI) p
CT-proET-1 > 74 pmol/L 2.658 (1.375–5.137) 0.004 2.663 (1.296–5.470) 0.008
Creatinine (per mg/dL) n.s.   
CRP (per mg/L) n.s.   
Bilirubin (per mg/dL) 1.129 (1.021–1.249) 0.018 n.s.
Prothrombin time (per %) 0.988 (0.977–1) 0.045 n.s.
Lactate (per mmol/L) 1.115 (1.03–1.207) 0.007 1.20 (1.109–1.298) <0.001
Age (per year) 1.034 (1.011–1.058) 0.003 1.045 (1.019–1.71) 0.003
  1. Variables with an univariate p < 0.25 were included in the multivariate model
  2. Abbreviations: 95%-CI, 95% confidence interval, CRP C-reactive protein, CT-proET-1 C-terminal proendothelin-1, n.s. not significant