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Table 3 Uni- and multivariate Cox regression analyses for CT-proET-1 levels at ICU admission to predict ICU mortality

From: C-terminal proendothelin-1 (CT-proET-1) is associated with organ failure and predicts mortality in critically ill patients

 

Unadjusted HR (95%-CI)

p

Adjusted HR (95%-CI)

p

CT-proET-1 > 74 pmol/L

2.658 (1.375–5.137)

0.004

2.663 (1.296–5.470)

0.008

Creatinine (per mg/dL)

n.s.

  

CRP (per mg/L)

n.s.

  

Bilirubin (per mg/dL)

1.129 (1.021–1.249)

0.018

n.s.

Prothrombin time (per %)

0.988 (0.977–1)

0.045

n.s.

Lactate (per mmol/L)

1.115 (1.03–1.207)

0.007

1.20 (1.109–1.298)

<0.001

Age (per year)

1.034 (1.011–1.058)

0.003

1.045 (1.019–1.71)

0.003

  1. Variables with an univariate p < 0.25 were included in the multivariate model
  2. Abbreviations: 95%-CI, 95% confidence interval, CRP C-reactive protein, CT-proET-1 C-terminal proendothelin-1, n.s. not significant