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Table 1 Baseline patient characteristics and CT-proET-1 serum measurements at ICU admission

From: C-terminal proendothelin-1 (CT-proET-1) is associated with organ failure and predicts mortality in critically ill patients

Parameter

All patients

Sepsis

Non-sepsis

p a

Number

217

144

73

 

Sex (male/female)

132/85

84/60

48/25

n.s.

Age median, (range) [years]

64 (18–90)

65 (20–90)

61 (18–85)

n.s.

APACHE-II score, median (range)

18 (2–43)

19 (4–43)

14 (2–33)

<0.001

SOFA score, median (range)

9 (0–17)

9 (2–17)

7 (0–17)

0.003

SAPS 2 score, median (range)

41 (0–73)

40 (0–73)

41 (0–73)

0.193

Mechanical ventilation, n (%)

144 (69)

98 (63)

46 (63)

n.s.

Ventilation time, median (range) [h]

117 (0–3828)

125.5 (0–2966)

66 (0–2828)

n.s.

Vasopressor demand, n (%)

132 (60.8)

99 (68.8)

33 (45.2)

<0.001

ICU days, median (range)

7 (1–137)

8.5 (1–137)

6 (1–45)

0.004

30-day mortality, n (%)

41 (18.9)

34 (23.6)

7 (9.6)

0.016

Overall mortality, n (%)

86 (41.7)

64 (46.7)

22 (31.9)

0.42

CT-proET-1, median (range) [pmol/L]

43.8 (3–503.6)

82.1 (3–503.6)

40.9 (3–372.9)

<0.001

Leucocytes, median (range) [per nL]

12.9 (0.5–208)

13.8 (0.5–208)

12.5 (1.8–29.6)

0.041

CRP, median (range) [mg/L]

98 (5–230)

160.5 (5–230)

17 (5–230)

<0.001

Cystatin C, median (range) [mg/L]

1.48 (0.39–8.38)

1.69 (0.39–8.38)

1.04 (0.56–2.29)

<0.001

Bilirubin, median (range) [per mg/dL]

0.7 (0.2–20.8)

0.7 (0.2–6.8)

0.7 (0.2–20.8)

n.s.

  1. For quantitative variables, median and range (in parenthesis) are given
  2. Abbreviations: CRP C-reactive protein, CT-proET-1 C-terminal proendothelin-1, APACHE Acute Physiology and Chronic Health Evaluation, SAPS 2 Simplified Acute Physiology Score, SOFA Sequential Organ Failure Assessment, n.s. not significant
  3. aSignificance between sepsis and non-sepsis patients was assessed using the Mann-Whitney U test or chi-squared test