Skip to main content

Table 1 Baseline patient characteristics and CT-proET-1 serum measurements at ICU admission

From: C-terminal proendothelin-1 (CT-proET-1) is associated with organ failure and predicts mortality in critically ill patients

Parameter All patients Sepsis Non-sepsis p a
Number 217 144 73  
Sex (male/female) 132/85 84/60 48/25 n.s.
Age median, (range) [years] 64 (18–90) 65 (20–90) 61 (18–85) n.s.
APACHE-II score, median (range) 18 (2–43) 19 (4–43) 14 (2–33) <0.001
SOFA score, median (range) 9 (0–17) 9 (2–17) 7 (0–17) 0.003
SAPS 2 score, median (range) 41 (0–73) 40 (0–73) 41 (0–73) 0.193
Mechanical ventilation, n (%) 144 (69) 98 (63) 46 (63) n.s.
Ventilation time, median (range) [h] 117 (0–3828) 125.5 (0–2966) 66 (0–2828) n.s.
Vasopressor demand, n (%) 132 (60.8) 99 (68.8) 33 (45.2) <0.001
ICU days, median (range) 7 (1–137) 8.5 (1–137) 6 (1–45) 0.004
30-day mortality, n (%) 41 (18.9) 34 (23.6) 7 (9.6) 0.016
Overall mortality, n (%) 86 (41.7) 64 (46.7) 22 (31.9) 0.42
CT-proET-1, median (range) [pmol/L] 43.8 (3–503.6) 82.1 (3–503.6) 40.9 (3–372.9) <0.001
Leucocytes, median (range) [per nL] 12.9 (0.5–208) 13.8 (0.5–208) 12.5 (1.8–29.6) 0.041
CRP, median (range) [mg/L] 98 (5–230) 160.5 (5–230) 17 (5–230) <0.001
Cystatin C, median (range) [mg/L] 1.48 (0.39–8.38) 1.69 (0.39–8.38) 1.04 (0.56–2.29) <0.001
Bilirubin, median (range) [per mg/dL] 0.7 (0.2–20.8) 0.7 (0.2–6.8) 0.7 (0.2–20.8) n.s.
  1. For quantitative variables, median and range (in parenthesis) are given
  2. Abbreviations: CRP C-reactive protein, CT-proET-1 C-terminal proendothelin-1, APACHE Acute Physiology and Chronic Health Evaluation, SAPS 2 Simplified Acute Physiology Score, SOFA Sequential Organ Failure Assessment, n.s. not significant
  3. aSignificance between sepsis and non-sepsis patients was assessed using the Mann-Whitney U test or chi-squared test