Fig. 2

Serum CT-proET-1 levels in critically ill patients are associated with organ failure. a–c Serum levels of CT-proET-1 at the time of admission to the ICU were significantly higher in critically ill patients with renal (cystatin C-based glomerular filtration rate (GFR) <50 mL/min; p < 0.001, U test), hepatic (prothrombin time <50%; p = 0.016) or cardiac failure (NTproBNP >1000 pg/mL; p < 0.001). d CT-proET-1 was not associated with the presence or severity of an acute respiratory distress syndrome (p = 0.715, Kruskal-Wallis test)