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Table 2 Effects of FFP/RBC ratio on mortality outcome

From: Trauma-induced coagulopathy and critical bleeding: the role of plasma and platelet transfusion

Authors

Year

Patients

FFP/RBC ratio

Results

Borgman

2007

246

<1:4 vs. 1:4—1:2 vs. >1:2

Improved in-hospital survival in highest ratio group (OR 8.6, CI 2.1–35.2)

Maegele

2008

713

<0.9 vs. 0.9—1.1 vs. >1.1

Decreased 30-day mortality in highest ratio group (24 vs. 46%, p < 0.001)

Duchesne

2008

135

<1:2 vs. >1:2

Increased mortality in low-ratio group (RR 18.9; CI 6.3–56.4)

Holcomb

2008

466

<1:2 vs. ≥1:2

Improved 30-day survival in high plasma transfusion group (73 vs. 43%, p < 0.001)

Zink

2009

466

<1:4 vs. 1:4—1:1 vs. ≥1:1

Decreased in-hospital mortality in high plasma transfusion groups (ARR of 29%)

Sperry

2008

415

<1:1.5 vs. ≥1:1.5

High plasma ratio is independently associated with lower mortality (HR 0.48, CI 0.3–0.8)

Gunter

2008

259

<2:3 vs. ≥2:3

Decreased 30-day morality in high plasma transfusion groups

Kashuk

2008

133

1:1 vs. 1:2 vs. 1:3 vs. 1:4 vs. ≥1:5

The lowest predicted mortality probability correlates with a plasma/red cell ratio of 1:2 and 1:3.

Teixeira

2009

383

≤1:8 vs. 1:8—1:3 vs. 1:3—1:2 vs. >1:2

Linear correlation between survival and plasma transfusion ratio. No survival advantage after plasma transfusion ratio reaches 1:3