Fig. 1

Conventional blood products and effects of administering them in ratios. a Composition of standard units of the following blood components: RBCs, FFP, and WBD PLTs. All PLT units in the Pragmatic Randomized Optimal Plasma and Platelet Ratios (PROPPR) study and 85% of PLTs used in the USA are in the form of apheresis units equal to six WBD units. The 55 billion PLTs in one WBD PLT unit occupy <0.5 mL. b Composition of the constituents in 1:1:1 and 1:1:2 mixtures of FFP, WBD PLTs, and RBC units. The top row is calculated directly from the contents, reflecting the extent to which anticoagulant and RBC additive solution dilute plasma and PLTs and RBCs are diluted by mixing with the other components. In the bottom row, the international normalized ratio and partial thromboplastin time values come from the experimental data of Kornblith et al. [23], whereas the circulating PLT counts given are 70% of the infused PLT counts to reflect the poor recovery of stored PLTs. Reproduced with permission [12]. RBCs red blood cells, FFP fresh frozen plasma, WBD whole blood-derived, PLTs platelets