Table 2 Characteristics of the included studies

 Shakur et al. [14]

2010

Adult trauma patients with, or at risk of, significant bleeding

20,127

10,060

10,067

N.A.

N.A.

N.A.

1.7^a

2.0^a

0.084

 Yutthakasemsun et al. [42]

2013

Adult trauma patients with moderate to severe traumatic brain injury (post-resuscitation Glasgow Coma Scale 4 to 12)

238

120

118

N.A.

N.A.

N.A.

0

0

–

 Morrison et al. [38]

2012

Patients who received at least 1 unit of PRBCs within 24 h of admission following combat-related injury

896

293

603

25.2

22.5

<0.001

2.7

0.3

0.001

 Swendsen et al. [41]

2013

Adult trauma patients who met triage criteria for serious injury and at least one of the following: hypotension, massive transfusion guideline activation, or transport directly to the operating room or interventional radiology suite

126

52

74

27.1

20.5

0.02

11.5

0

0.004

 Haren et al. [43]

2014

Adult trauma patients with hypercoagulable state defined as Greenfield’s risk assessment profile (RAP) ≥10

121

27

94

31

26

0.117

33

27

0.492

 Harvin et al. [44]

2014

Adult trauma patients with hyperfibrinolysis determined by rapid thrombelastography

1032

98

934

29

14

<0.001

6.3

4.4

0.389

 Cole et al. [19]

2015

Adult trauma patients with severe injury defined as injury severity score (ISS) >15

385

160

225

33

29

<0.05

5

4

ns

 Wafaisade et al. [45]

2016

Trauma patients with/without prehospital TXA administration

516

258

258

24

24

0.46

5.6

8.3

0.58