|
RCTs
|
|
Shakur et al. [14]
|
2010
|
Adult trauma patients with, or at risk of, significant bleeding
|
20,127
|
10,060
|
10,067
|
N.A.
|
N.A.
|
N.A.
|
1.7a
|
2.0a
|
0.084
|
|
Yutthakasemsun et al. [42]
|
2013
|
Adult trauma patients with moderate to severe traumatic brain injury (post-resuscitation Glasgow Coma Scale 4 to 12)
|
238
|
120
|
118
|
N.A.
|
N.A.
|
N.A.
|
0
|
0
|
–
|
|
Observational studies
|
|
Morrison et al. [38]
|
2012
|
Patients who received at least 1 unit of PRBCs within 24 h of admission following combat-related injury
|
896
|
293
|
603
|
25.2
|
22.5
|
<0.001
|
2.7
|
0.3
|
0.001
|
|
Swendsen et al. [41]
|
2013
|
Adult trauma patients who met triage criteria for serious injury and at least one of the following: hypotension, massive transfusion guideline activation, or transport directly to the operating room or interventional radiology suite
|
126
|
52
|
74
|
27.1
|
20.5
|
0.02
|
11.5
|
0
|
0.004
|
|
Haren et al. [43]
|
2014
|
Adult trauma patients with hypercoagulable state defined as Greenfield’s risk assessment profile (RAP) ≥10
|
121
|
27
|
94
|
31
|
26
|
0.117
|
33
|
27
|
0.492
|
|
Harvin et al. [44]
|
2014
|
Adult trauma patients with hyperfibrinolysis determined by rapid thrombelastography
|
1032
|
98
|
934
|
29
|
14
|
<0.001
|
6.3
|
4.4
|
0.389
|
|
Cole et al. [19]
|
2015
|
Adult trauma patients with severe injury defined as injury severity score (ISS) >15
|
385
|
160
|
225
|
33
|
29
|
<0.05
|
5
|
4
|
ns
|
|
Wafaisade et al. [45]
|
2016
|
Trauma patients with/without prehospital TXA administration
|
516
|
258
|
258
|
24
|
24
|
0.46
|
5.6
|
8.3
|
0.58
|
