Fig. 2

Spontaneous thrombin generation in severe trauma. a Stimulated thrombin generation curve. Although the amount of thrombin generation was lower in the Trauma group than the control group, time to initiation of thrombin generation and time to peak thrombin generation were shorter in the trauma group than the control group, suggesting coagulation activation. b Non-stimulated thrombin generation curve. Spontaneous thrombin generation was observed in the trauma group but not in the control group, demonstrating the presence of circulating procoagulants in the systemic circulation of the trauma group. Blue line: control group; red line: trauma group. (Cited as Figure 5 in our previous manuscript [27] and adapted with permission from Wolters Kluwer Health, Inc.)