Spontaneous thrombin generation in severe trauma cases. a Stimulated thrombin generation curve in control (blue) and trauma (red) groups. Although thrombin generation is lower in the trauma group than the control group, time to thrombin generation initiation and time to peak thrombin generation are shorter in trauma patients compared to control, suggesting coagulation activation. b Non-stimulated thrombin generation curve in the trauma (red) group. Spontaneous thrombin generation was not observed in the control group, demonstrating the presence of circulating pro-coagulants in the trauma group. This figure was adapted from  with permission from Wolters Kluwer Health, Inc.