High-mobility group box 1 is associated with neurological outcome in patients with post-cardiac arrest syndrome after out-of-hospital cardiac arrest

Table 2 Relationship between plasma levels of high-mobility group box 1, mitochondrial DNA, and physiologic parameters in patients after out-of-hospital cardiac arrest with return of spontaneous circulation

	HMGB-1 (day 1)		mtDNA (day 1)
	r	P value	r	P value
Estimated interval from collapse to ROSC	0.528	0.017	0.108	0.651
Initial lactate	0.715	0.000	0.463	0.034
Initial NH₃	0.674	0.001	0.168	0.478
Myoglobin (day 1)	0.555	0.011	0.310	0.184
APACHE-II	0.468	0.032	−0.315	0.559
IL-6 (day 1)	0.457	0.037	0.108	0.642
Maximal JAAM DIC	0.595	0.004	0.059	0.799
Maximal ISTH DIC	0.504	0.020	0.087	0.708

Abbreviations: ROSC return of spontaneous circulation, APACHE-II Acute Physiology and Chronic Health Evaluation II, IL interleukin, JAAM Japanese Association for Acute Medicine, ISTH International Society of Thrombosis and Haemostasis, DIC disseminated intravascular coagulation, SOFA Sequential Organ Failure Assessment, mtDNA mitochondrial DNA, HMGB-1 high-mobility group box 1

ISSN: 2052-0492