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Table 1 Characteristics and physiology of patients after out-of-hospital cardiac arrest

From: High-mobility group box 1 is associated with neurological outcome in patients with post-cardiac arrest syndrome after out-of-hospital cardiac arrest

Characteristic All patients (n = 21) Favourable group (n = 11) Unfavourable group (n = 10) P value
Age—years, median (IQR) 62.0 (47.0–79.0) 67.0 (36.0–76.0) 58.5 (47.0–83.0) 0.647
Male sex—no. (%) 13 (61.9 %) 8 (72.7 %) 5 (50 %) 0.387
Type of bystander-witness status—no. (%) 16 (76.2 %) 8 (72.7 %) 8 (80 %) 1.000
Bystander-initiated CPR—no. (%) 14 (66.7 %) 7 (72.7 %) 7 (70 %) 1.000
Cardiac origin—no. (%) 17 (81.0 %) 10 7 0.311
Initially documented rhythms on the scene of cardiac arrest—no.     0.123
 VF/pulseless VT 11 8 3  
 Non-VF/pulseless VT 10 3 7  
Estimated interval from collapse to ROSC—min 16.5 (13.0–29.5) 13.5 (10.0–16.25) 23.5 (16.75–44.25) 0.014
Therapeutic hypothermia—no. (%) 14 (66.7 %) 9 (81.8 %) 5 (50 %) 0.183
Initial lactate—mmol L−1   3.9 (2.4–7.5) 12.1 (7.08–15.70) 0.003
Initial NH3—μg dl−1   90.0 (41.0–140.0) 221.0 (90.5–345.5) 0.025
Myoglobin (day 1)—ng ml−1   402 (95–1343) 2008 (323–8358) 0.070
APACHE-II   24 (15–29) 30 (26–37) 0.072
IL-6 (day 1)—pg ml−1   23.5 (13.9–53.9) 88.0 (56.2–687.5) 0.024
Max IL-6—pg ml−1   84.9 (45.8–119.0) 196.5 (82.4–30637.5) 0.087
Max JAAM DIC   3.0 (2.0–4.0) 4.0 (2.0–6.25) 0.285
Max ISTH DIC   3.0 (2.0–3.0) 3.0 (2.75–5.5) 0.338
Max SOFA   10 (7.0–11.0) 10.0 (8.75–13.5) 0.499
Max d-dimer   7.0 (4.9–25.1) 24.7 (4.9–25.1) 0.074
Neurological outcomes 30 days after OHCA     
Survival (CPCs 1–4)—no. (%) 14 (66.7 %)    
 CPC 1, good performance 9    
 CPC 2, moderate disability 2    
 CPC 3, severe disability 1    
 CPC 4, vegetative state 2    
 CPC 5, death 7    
  1. Abbreviations: CPR cardiopulmonary resuscitation, VF ventricular fibrillation, VT ventricular tachycardia, ROSC return of spontaneous circulation, OHCA out-of-hospital cardiac arrest, CPC cerebral performance category scale, APACHE Acute Physiology and Chronic Health Evaluation, IL interleukin, JAAM Japanese Association for Acute Medicine, ISTH International Society of Thrombosis and Haemostasis, DIC disseminated intravascular coagulation, SOFA Sequential Organ Failure Assessment