Fig. 3

Management of myocardial dysfunction in septic shock. Prompt and adequate antibiotic therapy, accompanied by surgical removal of the infectious focus if indicated and feasible, is important to decrease PAMPs arising from invasive microorganisms. Early goal-directed therapy (EGDT), including fluid resuscitation, vasopressor and inotropic therapy, and red blood cell transfusion, is important to re-establish organ perfusion pressure, which helps maintain blood flow to tissues and reduces the release of damage-associated molecular patterns (DAMPs) in patients with septic shock. Sepsis bundle is a selected set of elements of care distilled from Surviving Sepsis Campaign guidelines. PAMPs pathogen-associated molecular patterns, PRRs pattern recognition receptors, SIRS systemic inflammatory response syndrome